patients on this arm will be treated with creapure supplements

patients on this arm will be given a placebo glucose tablet supplement

Juvenile Dermatomyositis

Patients will be prescribed a creapure supplement by weight, to be taken 3x/day for the duration of the trial. They will be randomized to an active product start time using a multiple baseline design.

Creapure

Patients will be prescribed the placebo supplement by weight, to be taken 3x/day for the duration of the trial. They will be randomized to an active product start time using a multiple baseline design.

Glucose Tablet

The Hospital for Sick Children

The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis

Will be determined by mean power output using a Wingate cycle ergometer protocol

The effects of creatine supplementation on key metabolites responsible for proper energy shuttling in healthy muscle will be measured at rest and using exercise protocols in subjects with P-MRS.

Both overall and health-related quality of life will be measured at each study visit with the Quality of My Life scale.

Will be measured using the International Myositis Assessment and Clinical Studies Group (IMACS) before and after creatine supplementation

Will be estimated at each study visit from a maximal jump test and hand grip strength.

Will be determined using the PedsQL fatigue module which has been validated for use in children with fibromyalgia and rheumatic disease.

This will be assessed based on a positive blood plasma and urine tests for creatine use over the course of the study period, amount of medication remaining and through self-reports using study diaries.

Brian Feldman

Division Head, Rheumatology / Sr Scientist

placebo of oseltamivir phosphate and placebo of Banlangen(Radix Isatidis) granules.

Banlangen(Radix Isatidis) granules and placebo of oseltamivir phosphate

oseltamivir phosphate and placebo of Banlangen(Radix Isatidis) granules

Influenza

placebo of oseltamivir phosphate

oseltamivir phosphate

Banlangen (Radix Isatidis) granules

placebo of Banlangen(Radix Isatidis) granules

Guangzhou Institute of Respiratory Disease

Banlangen Granules Anti-seasonal Influenza Study

Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled，Clinical Study.

The primary end point was the duration of illness which was defined as the time from onset of symptoms to the alleviation of the ten influenza-like symptoms including , nasal obstruction, running nose, cough, sore throat, headache, fatigue, myalgia, chills and sweating.

The time to defervescence, defined as the time from the first dose of study medication to the time when the body temperature declined to lower than 37.4ºC and was sustained for at least 24 hours.

viral shedding duration, defined as the time from the illness onset to the first time the viral nucleic acid test was negative

the severity of the disease,assessed by an area under the curve (AUC) analysis of a total of nine influenza-like symptom scores, the AUC was calculated as the product of the daily symptom scores times the duration of illness

incidence of secondary complications of influenza

Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited

Pulmonary Sarcoidosis

Meir medical center

Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study

Meir Medical Center

Irritable Bowel Syndrome

Link to Website of Alimentary Pharmabiotic Centre

Cork University Hospial

University College Cork

An Assessment of Cognitive Function in Irritable Bowel Syndrome

Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression

Cognitive assessments using CANTAB, a computerised cognitive assessment package

As assessment of IBS symptom severity using validated questionnaires

Plasma tryptophan, kynurenine, kynurenic acid, quinolinic acid

Psychiatric comorbidity will be assessed according to DSM-IV criteria

The potential confounding effect of sleep quality will be established using the Pittsburg Sleep Quality Index

Professor Ted Dinan

Science Foundation Ireland

American Neurogastroenterology and Motility Society

Men aged 65-75yr on Simvastatin therapy presenting with muscle soreness

Plasma, Muscle biopsy, Serum & Whole blood

myositis/fatigue

The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis

Banlangen Granules Anti-seasonal Influenza Study

Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study

An Assessment of Cognitive Function in Irritable Bowel Syndrome

Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy

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