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ocimum americanum/crise épileptique
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Biological effects of Ocimum gratissimum L. are due to synergic action among multiple compounds present in essential oil.
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Species of genus Ocimum (Lamiaceae) are economically important due to their essential oils and utilization as medicine for many disorders, including the central nervous system. A previous study showed seasonal variations in chemical profile and in central nervous system activities of essential oil
Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L. essential oil.
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Ocimum gratissimum L. (Lamiaceae) and other species of the same genus are used as medicines to treat central nervous system (CNS) diseases, commonly encountered in warm regions of the world. The chemical composition of Ocimum gratissimum essential oil varies according to their chemotypes: timol,
Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb.
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Anticonvulsant and anxiolytic activities of leaf extracts and fraction of Ocimum gratissimum L. (Lamiaceae) were studied using seizures induced by pentylenetetrazol and open-field tests in mice. The results showed that the extracts and fraction increased the latency of tonic and tonic-clonic
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
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For effective control of seizures, antiepileptic drugs (AEDs) are administered at higher dose which is associated with several adverse effects. This study envisaged antiepileptic and neuroprotective potential of Tulsi, a commonly used herb for its immunomodulatory property. The optimal dose of
Anticonvulsant potential of holy basil, Ocimum sanctum Linn., and its cultures.
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Callus cultures from stem of O. sanctum were induced on slightly modified Murashige and Skoog's (MS) medium and supplemented with 2,4-dichlorophenoxyacetic acid (2,4-D, 1-2 ppm) and kinetin (kn, 1 ppm). Different extractives of stem, leaf and stem callus of O. sanctum were tested for anticonvulsant
Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract.
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An ethanol extract of the leaves of Ocimum sanctum was screened for its effects on the central nervous system. It prolonged the time of lost reflex in mice due to pentobarbital, decreased the recovery time and severity of electroshock- and pentylenetetrazole-induced convulsions, and decreased
Evaluation of anti-amnesic effect of extracts of selected Ocimum species using in-vitro and in-vivo models.
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BACKGROUND
Ocimum species are traditionally used for the treatment of anxiety, nerve pain, convulsions and a variety of neurodegenerative disorders. The present study was undertaken to evaluate the anti-amnesic effect of O. basilicum L., O. sanctum L. and O. gratissimum L. extracts using in-vitro
An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy.
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