ovarian neoplasms/obésité

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Everolimus exhibits anti-tumorigenic activity in obesity-induced ovarian cancer.

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Everolimus inhibits mTOR kinase activity and its downstream targets by acting on mTORC1 and has anti-tumorigenic activity in ovarian cancer. Clinical and epidemiologic data find that obesity is associated with worse outcomes in ovarian cancer. In addition, obesity leads to hyperactivation of the

Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis.

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Obesity is a risk factor for several hormone-related cancers but evidence for an effect on risk of epithelial ovarian cancer remains inconclusive. Many studies evaluating this association have had insufficient statistical power to detect modest effects, particularly for histological subtypes of

Impact of obesity on chemotherapy dosing for women with advanced stage serous ovarian cancer in the Australian Ovarian Cancer Study (AOCS).

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OBJECTIVE Obesity is an increasing health problem that is reported to influence chemotherapy dosing. The extent to which this occurs and whether this affects outcomes in ovarian cancer was unclear. To describe chemotherapy dosing practices in normal, overweight and obese patients treated for FIGO

Hyperandrogenism, mediated by obesity and receptor polymorphisms, promotes aggressive epithelial ovarian cancer biology.

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OBJECTIVE Epidemiologic data suggest that aberrant androgen homeostasis may promote aggressive epithelial ovarian cancer biology. Hyperandrogenism results from both obesity and expression of polymorphic androgen receptor (AR) allelotypes harboring short cytosine-adenine-guanine (CAG) repeat

The pro-inflammatory effect of obesity on high grade serous ovarian cancer.

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Obesity is a known generator of chronic inflammation but has an uncertain role in ovarian carcinogenesis and survival. Pro-inflammatory cytokines have previously been associated with poor outcomes. Given the established links, we sought to determine whether obesity and pro-inflammatory cytokines

Neoadjuvant chemotherapy does not disproportionately influence post-operative complication rates or time to chemotherapy in obese patients with advanced-stage ovarian cancer

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Objectives: To determine whether neoadjuvant chemotherapy (NACT) disproportionately benefits obese patients. Methods: Data were collected from stage IIIC-IV ovarian cancer

The Impact of Obesity on the 30-day Morbidity and Mortality After Surgery for Ovarian Cancer.

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OBJECTIVE To examine the effect of body mass index (BMI) on postoperative 30-day morbidity and mortality after surgery for ovarian cancer (OC). METHODS Patients with OC were identified from the American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2011. Women were

Obesity, weight gain, and ovarian cancer.

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OBJECTIVE To investigate how adipose tissue alters endogenous hormone levels and may affect events at the ovarian tissue level. METHODS We assessed current weight, weight at age 18, and adult weight change in relation to ovarian cancer risk among 109,445 participants in the Nurses' Health Study.

[Morbidly obese patient with a huge ovarian tumor who was intubated while awake using airway scope in lateral decubitus position].

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A morbidly obese woman with a huge ovarian tumor was scheduled to undergo tumor resection under general anesthesia. Under slight sedation with midazolam and fentanyl, a tracheal tube was inserted smoothly using Pentax-AWS Airway Scope, and general anesthesia was thereafter maintained by sevoflurane.

Quality of life in ovarian cancer survivors: the influence of obesity.

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OBJECTIVE In this study, we evaluated the effect of body mass index (BMI) on the quality of life of ovarian cancer survivors. METHODS Women diagnosed with ovarian cancer at the Royal Cornwall Hospital Trust between January 2008 and May 2013 were identified. Ovarian cancer survivors were invited to

Association of obesity and ovarian cancer in a case-control study.

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Data from a population-based case-control study conducted in Washington State and Utah were used to assess whether obesity is associated with an altered risk of epithelial ovarian cancer. Quetelet index, defined as weight (kg) at age 30 years divided by height (m) squared, was calculated for each

DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

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OBJECTIVE Cigarette smoking is the leading cause of morbidity and mortality worldwide. We investigated the association between smoking behavior and genetic variations in the D2 dopamine receptor (DRD2), which mediates nicotine dependence. To assess the specificity of genetic effects, we also

Surgical morbidity and clinical outcomes in ovarian cancer - the role of obesity.

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OBJECTIVE To evaluate the effect of body mass index on the surgical outcomes in ovarian cancer patients. In addition, we performed a systematic review to compare our outcomes with the current literature. METHODS Retrospective cohort study and a systematic review of the

Childhood overweight, tallness and growth increase risks of ovarian cancer.

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BACKGROUND Adult body size is related to ovarian cancer risks, but size in childhood may also influence risks. We investigated if childhood body mass index (BMI; kg/m2), height, and growth patterns were associated with ovarian cancer overall and by histologic subtypes, including effects of

Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.

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Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved

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