200mg intravenous thiamine in 50ml 5% dextrose, single dose

50ml intravenous 5% dextrose, single dose

200mg intravenous thiamine in 50ml 5% dextrose, single dose
Thiamine: 200 mg IV thiamine

Thiamine

50ml intravenous 5% dextrose, single dose
Thiamine: 200 mg IV thiamine

Placebo

Total

Sex: Female, Male

Race (NIH/OMB)

The primary outcome will be the change in VO2 over the 6 hours after administration of the study medication, adjusted for baseline VO2.

Change in VO2 Over Time

Percentage Change in Serum Lactate

Change in central venous oxygen saturation

Change in Central Venous Oxygen Saturation

Overall Study

Dr. Katherine Berg

Critically Ill

Respiratory Failure

Beth Israel Deaconess Medical Center

The Effect of Thiamine vs. Placebo on VO2 in Critical Illness

Katherine Berg

Assistant Professor of Medicine

Open label - 200mg IV
Thiamine: 200mg of intravenous thiamine in 50ml of D5W will be infused over 30 minutes once

Ethnicity (NIH/OMB)

Region of Enrollment

VO2 measurements are taken at baseline and VO2 is continuously monitored over 9 hours. Thiamine is administered three hours after baseline measurements are taken.

Improvement in VO2

Hemodynamics were collected in all patients but we did not evaluate change in hemodynamics over the 9 hour protocol of the study. Due to the single-arm nature and small size of the study, and with no comparison arm, we did not think we had the statistical power to evaluate for a change in hemodynamics so this was not a planned outcome and was entered in error.

Improvement in Hemodynamics

Dr. Michael W. Donnino

Acute Respiratory Failure

200mg of intravenous thiamine in 50ml of D5W will be infused over 30 minutes once

pentose/hypoxie

The Effect of Thiamine vs. Placebo on VO2 in Critical Illness

Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

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