Intervention : Topical Melatonin(3%) at dosage of 15 mg once daily

Oral Leukoplakia

Topical melatonin at 3% concentration with dosage of 15 mg once daily will be applied on the lesion for 6 weeks followed by a follow up of 3 months

topical melatonin

Topical application of placebo once daily for 6 weeks with a follow up for 3 months

PLACEBO

Post graduate institute of dental sciences

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study

measurement of the lesion and scored according to RECIST criteria

Grading of dysplasia according to Speight classification (2007).

Percentage of a total number of Ki-67 positive cells to a total number of cells will be primarily deducted.

Postgraduate Institute of Dental Sciences Rohtak

active, moderate-to-severe Graves Orbitopathy according to EUGOGO.

Dysthyroid Orbit Neuropathy according to EUGOGO

Graves Disease

Graves Ophthalmopathy

Liver Diseases

Liver Failure

Liver Injury

Liver Dysfunction

Liver Insufficiency

Acute Liver Failure

Acute Liver Injury

Acute Liver Injury, Drug Induced

Methylprednisolone Adverse Reaction

Glucocorticoids Toxicity

Dysthyroid Orbitopathy

Dysthyroid Ophthalmopathy

12 pulses of intravenous methylprednisolone (IVMP) in every week schedule (for the first 6 weeks 0.5g IVMP per week, for the next 6 weeks 0.25g IVMP per week; cumulative dose 4.5g) according to EUGOGO recommendations

every week IVMP therapy

3 pulses of intravenous methylprednisolone (IVMP) (1.0g/day for 3 consecutive days; cumulative dose 3.0g) according to EUGOGO recommendations

very high doses IVMP therapy

Liver Function After Intravenous Methylprednisolone Administration

Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients With Graves' Orbitopathy

Administration of IVMP in 12 every week schedule: 6 weeks 0.5g IVMP per week plus 6 weeks 0.25g IVMP per week. Change of mean value of alanine aminotransferase (ALT) between baseline (before administration of IVMP) and the end of the therapy (after the last pulse of IVMP).

Administration of 3g IVMP (1g in 3 consecutive days). Change of mean value of ALT between baseline (before IVMP) and the end of the therapy (after the last pulse of IVMP).

Administration of IVMP in 12 every week schedule: 6 weeks 0.5g IVMP per week plus 6 weeks 0.25g IVMP per week. Depending on concentrations of ALT, liver dysfunction was divided into: mild (above the upper limit of normal but less than 100 U/L), moderate (100-300 U/L) and severe (>300 U/L). ALI was defined as an ALT concentration >300 U/L. Prevalence of all types of liver dysfunction was count after IVMP treatment.

Administration of 3g IVMP (1g in 3 consecutive days). Depending on concentrations of ALT, liver dysfunction was divided into: mild (above the upper limit of normal but less than 100 U/L), moderate (100-300 U/L) and severe (>300 U/L). ALI was defined as an ALT concentration >300 U/L. Prevalence of all types of liver dysfunction was count after IVMP treatment.

The collected data will be shared in a publication.

Piotr Miskiewicz

Assistant professor

Medical University of Warsaw

Control group will receive placebo medication therapy

pomegranate group will receive oral pomegranate (500 mg, twice per day)

Hearing Impairment

The gel contains a mixture of glucose and maltodextrin - a complex carbohydrate - along with fat and a trace of protein.

Placebo

Pomegranate

Dalin Tzu Chi Hospital

The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis

The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis: A Prospective, Randomized, Double-blinded Clinical Trial

pure tone thresholds of 250, 500, 1000, 2000, 4000, 8000 Hz were measured.

The speech recognition threshold is the lowest hearing level at which speech can barely be recognized or understood. The SRT is defined as the lowest hearing level at which the patient correctly repeats 50% of a list of spondaic words. Examples are airplane, hot dog, outside, ice cream, and baseball. Usually a very soft level (db HL).

The SDS test tool is a single syllable word list. Each table consists of 50 words, such as, look, go. The test method is to listen to the subject at a volume higher than the SRT value of 20 to 40 dB (30 dB), so that the subject repeats the spoken word sound. Based on the percentage of correct answers, normal people can repeat 95 to 100% of the words, and 80% or less of them are bad discriminating power and affect the understanding of language. SDS is usually expressed in %.

Dalin Tzu Chi General Hospital

Intravenous Methylprednisolone + Oral Methotrexate vs Intravenous Methylprednisolone + Placebo

Singapore National Centre

Thyroid Treatment Trial

Comparison of Efficacy and Safety of Intravenous Pulsed Methylprednisolone and Oral Methotrexate Versus Intravenous Pulsed Methylprednisolone and Oral Placebo in the Treatment of Active Moderate and Severe Thyroid Eye Disease - a Prospective, Randomized, Double-blind, Parallel, Controlled Multidisciplinary Clinical Trial and Imaging Study.

peroxidase/atrophie

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

Liver Function After Intravenous Methylprednisolone Administration

The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis

Thyroid Treatment Trial

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