phosphodiesterase/neoplasms

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Compositions comprising phosphodiesterase inhibitors for use in the treatment of a solid tumor in a human patient

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FIELD OF THE INVENTION The field of the invention relates to cancer biology. The present invention further relates to compositions and multi-drug combinations for use in the treatment of cancer. BACKGROUND OF THE INVENTION Approximately 1% of all human cancers are soft tissue sarcomas, which

Phosphodiesterase 9A as prostate cancer marker

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FIELD OF THE INVENTION The present invention relates to phosphodiesterase 9A (PDE9A) for use as a marker for prostate cancer, and the use of PDE9A as a marker for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer. The present invention also

Phosphodiesterase 4D7 as marker for malignant, hormone-sensitive prostate cancer

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FIELD OF THE INVENTION The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for malignant, hormone-sensitive prostate cancer, wherein the expression of the marker is increased when comparing the expression in malignant, hormone-sensitive prostate cancer tissue, to the

Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF)

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This invention relates to novel indazole analogs. The compounds are selective inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF), and as such are useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive airway disease, psoriasis,

1-Alkoxy-2-(alkoxy- or cycloalkoxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-) benzenes as inhibitors of cyclic AMP phosphodiesterase and tumor necrosis factor

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This application is a 371 of PCT/GB93/00445, filed on Mar. 4, 1993. FIELD OF THE INVENTION This invention is directed to sulfur-containing aromatic compounds which are useful in inhibiting cyclic AMP phosphodiesterase or tumor necrosis factor. The invention is also directed to the preparation of

Methods for using a phosphodiesterase in pharmaceutical screening to identify compounds for treatment of neoplasia

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BACKGROUND OF THE INVENTION This invention provides a method for identifying compounds potentially useful for the treatment and prevention of pre-cancerous and cancerous lesions in mammals. This application is a continuation of U.S. patent application Ser. No. 08/866,027 to Piazza et al. Filed May

Phosphodiesterase 4D7 as prostate cancer marker

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FIELD OF THE INVENTION The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for prostate cancer, and the use of PDE4D7 as a marker for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer. The present invention also

Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia

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BACKGROUND OF THE INVENTION This invention relates to a novel cGMP-specific phosphodiesterase that provides a method for identifying compounds potentially useful for the treatment and prevention of pre-cancerous and cancerous lesions in mammals. Cancer and precancer research is replete with

Substituted pyrido[2,3-c]pyridazin-4(1H)-ones as tumor necrosis factor alpha and phosphodiesterase 4 inhibitors

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TECHNICAL FIELD The present invention relates to field of medical technology, specifically relates to a pyridino-oxopyridazine derivative, its pharmaceutically acceptable salts, its stereoisomers or its solvates, their preparation methods, a pharmaceutical composition comprising the compound, and

Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors

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FIELD OF THE INVENTION The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple

Method for treating a patient with neoplasia using Iressa

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BACKGROUND OF THE INVENTION Virtually all of the many anti-neoplastic drugs that are currently used in the treatment of cancer have very serious and harmful side effects. This is because cancer is generally treated with medications that interfere with the growth of rapidly dividing cells. Such

Pyrrolopyrimidines as phosphodiesterase VII inhibitors

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The invention relates to compounds of the formula I ##STR00002## in which X is phenyl or Het, each of which is unsubstituted or monosubstituted or polysubstituted by R.sup.1 and/or R.sup.2, R.sup.1 and R.sup.2 are each, independently of one another, A, OH, OA, SA, SOA, SO.sub.2A, SO.sub.2NH.sub.2,

Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors

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The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a, a process for preparing those compounds and a method of treating cancer by administering those compounds. Cyclic AMP metabolism is regulated by the opposing activities of adenylyl

Thiazole derivatives as phosphodiesterase IV inhibitors

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The invention relates to compounds of the formula I ##STR00002## in which R.sup.1 and R.sup.2 are each, independently of one another, H, OH, OR.sup.8, --SR.sup.8, --SOR.sup.8, --SO.sub.2R.sup.8 or Hal, R.sup.1 and R.sup.2 together are alternatively --OCH.sub.2O-- or --OCH.sub.2CH.sub.2O--, R.sup.3

Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-.alpha., and IL-4

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FIELD OF THE INVENTION The present invention relates to a novel thiazole compound. The present invention further relates to a pharmaceutical composition comprising the thiazole compound. BACKGROUND OF THE INVENTION Researchers have recently discovered that cyclic adenosine 3',5'-monophosphate

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