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CROSS REFERENCE TO RELATED APPLICATION
This Application claims the benefit of U.S. Provisional Application Ser. No. 61/444,566 filed Feb. 18, 2011, which is incorporated by reference herein in its entirety.
BACKGROUND OF THE INVENTION
Phosphodiesterases (PDEs) are a class of intracellular enzymes
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BACKGROUND OF THE INVENTION
Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and
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BACKGROUND OF THE INVENTION
Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and
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BACKGROUND OF THE INVENTION
Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and
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I. CROSS-REFERENCE TO RELATED APPLICATION
This application claims priority to U.S. Provisional Patent Application No. 61/431,769, filed Jan. 11, 2011, the content of which is hereby incorporated by reference herein in its entirety.
II. FIELD
Provided herein are heteroaryl compounds useful for
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The contents of the text file named SYPA-003_C04US_SeqList_ST25.txt, which was created on Jun. 17, 2015 and is 107 KB in size, are hereby incorporated by reference in their entirety.
FIELD OF THE INVENTION
The present invention relates to the therapeutic use of guanylate cyclase C (GC-C) agonists as
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FIELD OF THE INVENTION
Provided herein are certain aminopyridine and carboxypyridine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by
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FIELD OF THE INVENTION
Provided herein are certain pyrazine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10,
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FIELD OF THE INVENTION
Provided herein are certain pyrazine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10,
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FIELD OF THE INVENTION
Provided herein are certain pyrazine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10,
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FIELD OF THE INVENTION
Provided herein are certain pyridine and pyrimidine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by
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FIELD OF THE INVENTION
Provided herein are certain pyridine and pyrimidine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by
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TECHNICAL FIELD
The present invention relates to a piperidine derivative.
More specifically, the present invention relates to (1) a piperidine derivative of formula (I)
##STR00002## (2) a method for the preparation thereof, (3) a composition comprising it as an active ingredient, (4) a compound of
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COMBINATIONS
The present invention relates to a combination, especially a pharmaceutical composition, comprising (a) a PDE 5 inhibitor or a pharmaceutically acceptable salt thereof and (b) at least one active ingredient selected from the group consisting of (i) an anti-diabetic agent; (ii) HMG-Co-A
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