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phosphodiesterase/obésité

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Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)

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CROSS REFERENCE TO RELATED APPLICATION This Application claims the benefit of U.S. Provisional Application Ser. No. 61/444,566 filed Feb. 18, 2011, which is incorporated by reference herein in its entirety. BACKGROUND OF THE INVENTION Phosphodiesterases (PDEs) are a class of intracellular enzymes

Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)

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BACKGROUND OF THE INVENTION Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and

Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)

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BACKGROUND OF THE INVENTION Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and

Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)

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BACKGROUND OF THE INVENTION Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and

[1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases

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I. CROSS-REFERENCE TO RELATED APPLICATION This application claims priority to U.S. Provisional Patent Application No. 61/431,769, filed Jan. 11, 2011, the content of which is hereby incorporated by reference herein in its entirety. II. FIELD Provided herein are heteroaryl compounds useful for
The contents of the text file named SYPA-003_C04US_SeqList_ST25.txt, which was created on Jun. 17, 2015 and is 107 KB in size, are hereby incorporated by reference in their entirety. FIELD OF THE INVENTION The present invention relates to the therapeutic use of guanylate cyclase C (GC-C) agonists as

Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors

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FIELD OF THE INVENTION Provided herein are certain aminopyridine and carboxypyridine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by

Pyrazine compounds as phosphodiesterase 10 inhibitors

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FIELD OF THE INVENTION Provided herein are certain pyrazine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10,

Pyrazine compounds as phosphodiesterase 10 inhibitors

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FIELD OF THE INVENTION Provided herein are certain pyrazine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10,

Pyrazine compounds as phosphodiesterase 10 inhibitors

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FIELD OF THE INVENTION Provided herein are certain pyrazine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10,

Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors

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FIELD OF THE INVENTION Provided herein are certain pyridine and pyrimidine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by

Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors

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FIELD OF THE INVENTION Provided herein are certain pyridine and pyrimidine compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by

Piperidine derivative compounds and drugs containing the compounds as the active ingredient

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TECHNICAL FIELD The present invention relates to a piperidine derivative. More specifically, the present invention relates to (1) a piperidine derivative of formula (I) ##STR00002## (2) a method for the preparation thereof, (3) a composition comprising it as an active ingredient, (4) a compound of

Combinations

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COMBINATIONS The present invention relates to a combination, especially a pharmaceutical composition, comprising (a) a PDE 5 inhibitor or a pharmaceutically acceptable salt thereof and (b) at least one active ingredient selected from the group consisting of (i) an anti-diabetic agent; (ii) HMG-Co-A
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