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podophyllotoxin/neoplasms
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4.beta.-amino podophyllotoxin congeners as anti tumour antibiotics a process for the preparation thereof
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FIELD OF THE INVENTION
The present invention relates to novel 4.beta.-amino podophyllotoxin congeners as antitumour antibiotics. More particularly, the present invention relates to novel .beta.-amino podophyllotoxin congeners of general formula A
##STR00002##
The present invention also relates to a
Podophyllotoxin derivatives
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FIELD OF THE INVENTION
This invention relates to novel derivatives of podophyllotoxin that are useful for treating various types of cancer.
BACKGROUND OF THE INVENTION
Podophyllotoxin is a known compound having the formula:
##STR00001## The compound shows activity as an antiviral and as an
Podophyllotoxin derivatives
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INTRODUCTION
1. Field of the Invention
This invention relates to novel derivatives of podophyllotoxin that are useful for treating various types of cancer.
2. Background of the Invention
Podophyllotoxin is a known compound having the formula:
##STR00001## The compound shows activity as an antiviral
Podophyllotoxin derivatives
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INTRODUCTION
1. Field of the Invention
This invention relates to novel derivatives of podophyllotoxin that are useful for treating various types of cancer.
2. Background of the Invention
Podophyllotoxin is a known compound having the formula:
##STR00001## The compound shows activity as an antiviral
4.beta.-amino podophyllotoxin analog compounds and methods
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FIELD OF THE INVENTION
The present invention relates to novel 4.beta.-amino podophyllotoxin analog compounds useful in the treatment of tumors, to methods of synthesis of the compounds, and to methods of treating tumors with pharmaceutical preparations containing the compounds.
References
Ayers, et
4 beta-amino podophyllotoxin analog compounds and methods
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1. Field of the Invention
The present invention relates to novel 4.beta.-amino podophyllotoxin analog compounds useful in the treatment of tumors, to methods of synthesis of the compounds, and to methods of treating tumors with pharmaceutical preparations containing the compounds.
2.
Gem-difluorinated C-glycoside compounds as anti-cancer agents
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BACKGROUND
(a) Field
The subject matter disclosed generally relates to novel chemical compounds and methods. More particularly, the invention provides novel derivatives of podophyllotoxin with a gem-difluoronated compound, having improved conformational and chemical stability, and having improved
Etoposide and prodrugs thereof for use in targeting cancer stem cells
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FIELD OF THE INVENTION
The present invention pertains to the use of podophyllotoxin derivatives, such as CAP7.1, in methods for inhibition of and/or prevention of the growth and/or survival of cancer stem cells (CSC). The invention discloses the surprisingly specific activity of the compounds in
4.beta.-1''-[(2''-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents
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TECHNICAL FIELD
The present invention relates to a process for the synthesis of new 4.beta.-1''-[2''-(substituted benzoyl)anilino]podophyllotoxin analogues are useful anticancer agents. The present invention particularly relates to the synthesis of new class of 4.beta.-O-benzoyl anilino congeners of
Gem-difluorinated C-glycoside compounds derived from podophyllotoxin, their preparation and their applications
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a method for the synthesis of gem-difluorinated C-glycoside compounds derived from podophyllotoxin. It more particularly, but not exclusively, applies to the preparation of compounds which may be notably used in oncology
Podophyllotoxin derivatives and their use
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FIELD
The present disclosure relates to derivatives of podophyllotoxin, compositions thereof, and using them for treating various types of cancer in a subject and/or delaying or regressing various types of tumor growths in a subject.
STATE OF THE ART
Podophyllotoxin is a known compound having the
Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them
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The present invention relates to new carbamate and thiocarbamate podophyllotoxin compounds, to a process for their preparation and to pharmaceutical compositions containing them.
The compounds of the invention are derivatives of podophyllotoxin, a natural lignan known for its use in the treatment of
Anti-integrin immunoconjugates, methods and uses
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to conjugates of tumor specific antibodies with cytotoxic compounds. The preferred conjugates contain maytansinoid compounds linked to an anti-integrin antibody by a disulfide linkage.
2. Background of the Invention
There
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