Chinese patients with clinical suspicious of prostate cancer, due to elevated serum PSA or abnormal digital rectal examination, will be recruited for the study from the Prince of Wales Hospital and North District Hospital.

Serum PSA level will be collected. Up to 100cc of urine will be freshly collected from patient before they undergo prostate biopsy.

Prostate Cancer

The Spermine Measuring Device (SMD) is a simple device, with automatic urine aspiration and also spermine level assessment. First about 30 cc urine will be freshly collected by a prepared collection device. Then the cap of the SMD will be removed and the aspiration tip of the device will be immersed into the urine specimen. After firmly pressed on the device, a small sample of urine will be aspirated into the SMD. The device will then automatically assess the urine spermine level. The result will then be read at a indicator window after about 5 minutes. If the level was below a pre-set cutoff, i.e. suggestive of having increase risk of prostate cancer, the indicator window will turn into red colour. However, if the spermine level is higher than the cutoff value, i.e. low risk of having cancer, the indicator window will turn blue.

Spermine Measuring Device

Prince of Wales Hospital

Spermine Measuring Device Evaluation Protocol

To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result

By comparing the urine spermine level results of the spermine measuring device with the prostate biopsy pathology

By comparing the urine spermine level results of the spermine measuring device with that of the liquid chromatography

Chi Fai NG

Principal Investigator

Chinese University of Hong Kong

To Identify Potential New Urine Markers for the Screening of Prostate Cancer

Fresh urine will be collected for liquid chromatography and mass spectrometry to detect the concentration of spermine in urine. Then the The correlation between the concentration of urine spermine and serum PSA level and pathological result will be assessed.

Fresh urine will be collected for liquid chromatography and mass spectrometry to detect the concentration of spermine in urine. Then the The correlation between the concentration of urine spermine and pathological result and serum PSA level will be assessed.

Professor

Breast Cancer

Surgery

Polyamine-free diet in the 7 days befor surgery

polyamine-free diet

Peroperative and post operative (48h) ketamine injection

polyamine/cancer du sein

Spermine Measuring Device Evaluation Protocol

To Identify Potential New Urine Markers for the Screening of Prostate Cancer

Polyamine-free Diet to Prevent Post Surgery Hyperalgesia

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