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portuguese/hypoxie
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Lack of relevance of HIF-1α polymorphisms in breast cancer in a Portuguese population.
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We aimed to study the prevalence of Hypoxia inducible factor-1α (HIF-1α) P582S and A588T polymorphisms in a Portuguese breast cancer population and its effect on the transcriptional activity of HIF-1α in MCF7 breast adenocarcinoma cells. We performed a polymerase chain Reaction--restriction fragment
Hypoxia and renal cell carcinoma: The influence of HIF1A+1772C/T functional genetic polymorphism on prognosis.
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Hypoxia-inducible factor (HIF-1) is a key regulator of the genes involved in the cellular response to hypoxia. Overexpression of HIF-1 has been implicated in the pathogenesis of renal cell carcinoma (RCC), and functional polymorphisms of the HIF1A gene may confer susceptibility to RCC. Our purpose
Flight physiology training experiences and perspectives: survey of 117 pilots.
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BACKGROUND
Human factors and awareness of flight physiology play a crucial role in flight safety. Even so, international legislation is vague relative to training requirements in hypoxia and altitude physiology.
METHODS
Based on a previously developed survey, an adapted questionnaire was formulated
Association of alveolar recruitment maneuvers and prone position in acute respiratory disease syndrome patients.
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The acute respiratory distress syndrome is the clinical presentation of acute lung injury characterized by diffuse alveolar damage and development of non-cardiogenic pulmonary edema due to increased pulmonary alveolar-capillary membrane permeability. Alveolar recruitment maneuvers and prone position
Ethnic variability of HIF-1alpha polymorphisms.
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The hypoxia-inducible factor -1alpha (HIF-1alpha) is a transcription factor that plays a crucial role in the cellular response to hypoxia. The C1772T (P582S) and G1790A (A588T) polymorphisms, within the oxygen dependent degradation domain of HIF-1alpha protein, seem to be important in the oxygen
Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies.
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The carotid bodies (CBs) are peripheral chemoreceptors that respond to hypoxia increasing minute ventilation and activating the sympathetic nervous system. Besides its role in ventilation we recently described that CB regulate peripheral insulin sensitivity. Knowing that the CB is functionally
Alveolar recruitment maneuver in mechanic ventilation pediatric intensive care unit children.
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Recent changes were introduced in acute hypoxemic respiratory failure children ventilation methods. There are evidences that less aggressive ventilation strategies can improve severe pulmonary injury survival. Experimental trials evidenced a relationship between inappropriate ventilatory measures
High-frequency oscillatory ventilation in children: a 10-year experience.
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OBJECTIVE
The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation.
METHODS
This was a retrospective observational cohort study
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