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Hydrops from reciprocating atrioventricular tachycardia in a 27-week fetus requiring quinidine for conversion.
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A 27-week fetus with severe nonimmune hydrops was found to have a reciprocating atrioventricular tachycardia with the rate of 275 beats per minute. Maternal digitalization produced improvement without conversion. Large doses of propranolol were without effect. Twelve days later quinidine was added,
Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis.
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Intestinal circulatory disturbances, atony, edema and swelling are of great clinical relevance, but the related mechanisms and possible therapeutic options are poorly characterized, in part because of the difficulties to comprehensively analyze these conditions. To overcome these limitations we have
CRPS-related neurogenic edema responsive to dextromethorphan/quinidine.
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Neonatal paroxysmal supraventricular tachycardia with hydrops.
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A critically ill infant with paroxysmal supraventricular tachycardia and hydrops fetalis responded well to aggressive management. Care must be taken to avoid digitalis toxicity. Procaine amide or quinidine are effective alternate therapies.
The management of acute quinidine intoxication.
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A 16-year-old patient survived severe intoxication with quinidine. Hypotension, rapidly progressing to oliguria and shock, was resistant to the usual therapeutic interventions but responded favorably to the use of an intra-aortic balloon pump. Some hemodynamic implications are discussed. Pulmonary
Atrial fibrillation in horses: factors associated with response to quinidine sulfate in 77 clinical cases.
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Seventy-seven horses with atrial fibrillation (AF) were treated orally with quinidine sulfate (QS) at the University of Pennsylvania, School of Veterinary Medicine, Thirty-seven horses (48%) had adverse reactions to QS, the most common of which were nasal mucosal edema, anorexia, colic, and
Fetal ventricular tachycardia associated with nonimmunologic hydrops fetalis. A case report.
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A very rare case occurred of fetal ventricular tachycardia associated with nonimmunologic hydrops fetalis and diagnosed on echocardiography. Attempted cardioversion with quinidine was unsuccessful.
Case Report: A Case of Severe Cerebral Malaria Managed with Therapeutic Hypothermia and Other Modalities for Brain Edema.
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Malarial infections are uncommon in the United States and almost all reported cases stem from recent travelers coming from endemic countries. Cerebral malaria (CM) is a severe form of the disease usually affecting children and individuals with limited immunity. Despite proper management, mortality
Dynamics of systemic quinidine photoallergy in the mouse.
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Photoallergy to systemically administered quinidine was induced in the mouse, and the minimal time for sensitization as well as the duration of the allergy were studied. When groups of female albino mice, pretreated with cyclophosphamide, were exposed to quinidine 100 mg/kg i.p. followed by 0.1
Phototoxic properties of quinine and quinidine: two quinoline methanol isomers.
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Clinical photoreactions have been reported for quinine and quinidine after systemic and topical administration. We have investigated the phototoxic properties of these two quinoline methanol isomers in vitro using the Candida albicans inhibition test and photohemolysis, and in vivo with the mouse
Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation.
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In the present study we have investigated the mechanisms of pulmonary edema caused by platelet-activating factor (PAF) in isolated rat lungs as well as in mice in vivo. In blood-free perfused and ventilated rat lungs, PAF increased lung weight by 0.59 +/- 0.18 g. The cyclooxygenase inhibitor aspirin
Refractory fetal supraventricular tachycardia with hydrops: report of one case.
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Fetal tachycardia sometimes is quite difficult to treat, especially when the fetus has congestive heart failure. Sustained supraventricular tachycardia and hydrops had been diagnosed in a fetus as early as the 27th week of gestational age. A variety of antiarrhythmic agents, including digoxin,
Nonimmunologic hydrops fetalis: a review of 11 cases.
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Eleven cases of nonimmunologic hydrops fetalis occurring during a six year period were reviewed. The etiology of hydrops fetalis was established only in four cases. It included one case of endocardial fibrosis, two cases of non-immunologic hemolysis and one case of tachycardia. The pregnancies were
Treatment of cardiac arrhythmias during pregnancy: safety considerations.
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Maternal and fetal arrhythmias occurring during pregnancy may jeopardise the life of the mother and the fetus. When arrhythmias are well tolerated and patients are minimally symptomatic, conservative therapy, such as observation and rest or vagal manoeuvres, should be employed. When arrhythmias
Pharmacology and pharmacokinetics of drugs used to treat cardiac disease in horses.
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The rational therapy of cardiovascular disease in horses requires a thorough knowledge of the pharmacology and pharmacokinetics of several specific drugs (digitalis, digoxin). Calcium solutions, dopamine, and dobutamine are frequently used to treat congestive heart failure in horses. Quinidine,
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