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Treatment of severe falciparum malaria during pregnancy with quinidine and exchange transfusion.
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Malaria during pregnancy may be associated with significant morbidity and mortality in both mother and fetus. Treatment of severe chloroquine-resistant malaria during pregnancy may be problematic since quinine and related compounds may have a deleterious effect on the course of labor. This article
The hemodynamic effects of sotalol and quinidine: analysis by use of rest and exercise gated radionuclide angiography.
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This placebo-controlled, double-blind trial compared the hemodynamic effects of sotalol and quinidine with the use of rest and exercise gated radionuclide angiography. Patients had frequent ventricular premature depolarizations (greater than or equal to 30 VPDs/hour) and depressed cardiac function
[Comparative effectiveness of ethmozine, mexitil, quinidine and obsidan in the treatment of ventricular rhythm disorders].
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A comparative assessment of efficacy of the drugs in a group of patients with frequent ventricular extrasystoles has shown that ethmozine and mexitil are effective in most of cases. In certain patients deterioration of the rhythm after all these drugs (ethmozine, mexitil, quinidine, obsidan) has
A functional psychosis precipitated by quinidine.
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A 62-year-old man with a syndrome of gradually progressive cognitive deterioration accompanied by paranoid features is described. He had been taking quinidine since 1974 for a recurring supraventricular tachyarrhythmia. Examination revealed a suspicious man with widespread patchy cognitive deficits
Difficulties in diagnosing Leber's optic atrophy.
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The lowered vision of a patient was attributed to an acute quinidine intoxication, although his condition differed from that of another patient with an acute quinine intoxication. Later, the uncle of the first patient showed lowered vision too, possibly due to a tobacco-alcohol neuropathy. Both
High-performance liquid chromatography of quinidine in plasma, with use of a microparticulate silica column.
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We describe a routine method for determining plasma concentrations of quinidine by liquid chromatography. The procedure requires 1.0 ml of plasma (or serum) and involves internal standard addition, extraction with ether, and separation on a column of microparticulate silica. Day-to-day CV (15 days)
Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer.
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Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new
Combined administration of quinidine with the beta-adrenolytic agent inderal and the local anaesthetic of the beta-aminoketone group, hexacaine, in various experimental models of arrhythmias.
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If the antiarrhythmic agents mentioned above are administered in combinations of their respective isoeffective doses, following the "principle of isoeffectivity", a potentiation of their effects takes place. The authors describe methods for the preparation of combined solutions and for the toxicity
Using pharmacokinetics in drug therapy. VII: Pharmacokinetic factors influencing drug therapy in the aged.
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The pharmacokinetic factors influencing drug therapy in the elderly are reviewed with special attention on dosage regimens. Deterioration in the effectiveness of drug clearance appears to be the principal pharmacokinetic factor that is altered with age. Prolonged half-life and reduced volume of
Hemodynamics before and after conversion of atrial fibrillation to normal sinus rhythm in horses.
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Hemodynamic measurements were obtained from 17 horses with atrial fibrillation or flutter. Eight horses had atrial fibrillation of unknown duration. In 7 horses, atrial fibrillation developed during anesthesia. Atrial flutter developed during recovery from anesthesia in 2 horses. Hemodynamic
Acetylcholine receptor gating in a zebrafish model for slow-channel syndrome.
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Slow-channel syndrome (SCS) is an autosomal-dominant disease resulting from mutations in muscle acetylcholine (ACh) receptor subunits. The associated fatigue and muscle degeneration are proposed to result from prolonged synaptic responses that overload intracellular calcium. Single-channel studies
Determination of plasma procainamide and N-acetylprocainamide concentration by high-pressure liquid chromatography.
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We describe a routine method for determining concentrations of the antiarrhythmic drug procainamide and its active metabolite, N-acetylprocainamide, in plasma. A simple extraction of 1.0 ml of plasma is followed by separation and chromatographic analysis by use of a column containing
The effect of antiarrhythmic drugs on depressed conduction and unidirectional block in sheep Purkinje fibers.
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We studied the effect of therapeutic concentrations of lidocaine, procainamide, quinidine, propranolol, and diphenylhydantoin on two models of depressed conduction and unidirectional block produced by asymmetric focal cooling and crushing in sheep Purkinje fibers. All drugs were shown to induce
Ventricular fibrillation in Wolff-Parkinson-White syndrome, type A.
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A young individual who developed ventricular fibrillation following atrial fibrillation in the WPW syndrome is presented. The precise cardiac rhythm diagnosis is extremely important for proper management. When the QRS morphology is bizarre and the ventricular rate is very fast (200 to 300 b.p.m.) in
[Arrhythmogenic effects of antidepressive agents demonstrated by programmed ventricular pacing].
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Tricyclic antidepressants and phenothiazines have been blamed for increasing the incidence of sudden death. One of their known mechanisms of action in such cases is to induce torsades de pointes by a so-called "quinidine-like" effect. We report the case of a female patient who was rescued from an
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