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Distribution of antidepressants between plasma and red blood cells.
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OBJECTIVE
The distribution of different antidepressants between plasma and red blood cells (RBCs) or between water and erythrocyte membranes (ghosts) has not been sufficiently compared so far.
METHODS
Distribution of seven antidepressants (amitriptyline, nortriptyline, imipramine, desipramine,
Antidepressant-like effect of altered Korean red ginseng in mice.
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Altered Korean red ginseng has been used as a treatment for patients suffering from anxiety. We assessed whether red ginseng hydrolyzed by malted barley (HRG) and acetate-fermented red ginseng (ARG) would improve brain activity, by using forced swimming test (FST) in mice. The effect of the
Uptake and/or binding of tricyclic antidepressants in human red cells.
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The factors affecting the red blood cells (RBC) uptake and/or binding of tricyclic antidepressants imipramine (IMI) and desmethylimipramine (DMI) were investigated under in vitro conditions. The time course of drug distribution indicated that equilibrium between RBC and medium is reached rapidly.
Effects of some phenothiazines, tricyclic antidepressants and antihistamines on red cell agglutination.
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Red cell and plasma concentrations of fluoxetine and norfluoxetine.
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To study the distribution of fluoxetine and norfluoxetine in blood compartments we determined their concentrations in red cells and plasma after the addition of 500 ng/ml of each compound to human blood in vitro. Red cell and plasma fluoxetine concentrations were 493 +/- 79 ng/ml and 454 +/- 53
Red blood cell L-tryptophan uptake in depression. II. Effect of an antidepressant treatment.
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The evolution of the kinetic parameters, maximal velocity (Vmax) and Michaelis constant (Km), of L-tryptophan (L-TRP) uptake into red blood cells (RBC) was studied in 30 depressed patients in a drug-free state (D0) and after 1 week (D7) and 4 weeks (D28) of a treatment involving a variety of
Tricyclic antidepressants in red cells and plasma: correlation with impaired intraventricular conduction in acute overdose.
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OBJECTIVE
Tricyclic antidepressant levels in red blood cells and plasma in acute overdose and their association with cardiotoxicity were studied.
METHODS
This was a prospective study in 15 patients with acute tricyclic antidepressant overdose. Tricyclic antidepressant parent compounds and
Blue but not red light stimulation in the dark has antidepressant effect in behavioral despair.
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The present study investigated potential antidepressant effect of light exposure in the dark phase of a 12:12 L/D cycle on behavioral despair. In Exp.1, male Wistar rats were administered a single, 10 min broadband light pulse (1300lx) either 3h (ZT15) or 9h (ZT21) after dark onset (ZT12) and tested
Red blood cell triiodothyronine uptake in unipolar major depression: effect of a chronic antidepressant treatment.
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The evolution of kinetic parameters (Vmax, maximal velocity, and Km, Michaelis constant) of red blood cell (RBC) triiodothyronine (L-T3) initial uptake was followed in 19 inpatients suffering from unipolar depression after 1 week (D7) and 4 weeks (D28) of a chronic administration of fluvoxamine, in
Imipramine distribution among red blood cells, plasma and brain tissue.
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The relations between the concentrations of a drug in the blood (plasma, haemoglobin, red blood cells (RBCs), RBC membranes) and in the brain tissue (homogenate, membranes, cytosol) were investigated during chronic administration of imipramine. Radioimmunoassay was employed to measure the
Treatment of seasonal affective disorder with green light and red light.
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OBJECTIVE
This study sought to determine whether an equal photon density of green light is superior to red light in treating seasonal affective disorder.
METHODS
After recruitment through the media, 20 outpatients with seasonal affective disorder participated in a balanced-order crossover trial of 1
Binedaline binding to plasma proteins and red blood cells in humans.
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Serum binding of binedaline, a new antidepressant drug, was studied in vitro by equilibrium dialysis. The percent of binding in serum is high, 99.2%, and remains constant within the range of therapeutic concentrations; no saturation to the binding sites was seen. Investigations performed on isolated
Demonstration of a Na+: Mg2+ exchange in human red cells by its sensitivity to tricyclic antidepressant drugs.
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Iminodibenzyl-, iminostilbene-, dibenzocycloheptadiene-, dibenzooxepine- and dibenzothiepine-derivatives of tricyclic antidepressant drugs were able to inhibit Na+-stimulated Mg2+ efflux in human erythrocytes at concentrations of 10(-5) -10(-3) mol/l. Tricyclic antidepressant drugs belonging to
Investigations on electrolyte and water contents in plasma and red blood cells in the course of thymoleptic treatment of depressive syndromes.
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Water and electrolyte contents in plasma and red blood cells (RBC) were studied in 46 patients with depressive syndromes of various etiology (bipolar, unipolar, psychogenic) before and after 14 days of imipramine treatment. Initial low RBC sodium levels were characteristic of patients with bipolar
Involvement of the dopaminergic system in the antidepressant-like effect of the lectin isolated from the red marine alga Solieria filiformis in mice.
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This study aimed at evaluating the antidepressant-like action of the marine alga Solieria filiformis lectin (SfL) and to investigate the participation of the monoaminergic system in this action. For this, male Swiss mice (n=10) were pretreated with intravenous injections (i.v.) of SfL (1, 3 or
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