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Effect of hypoxia on human seminoma cells.
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Since hypoxia has been considered to enhance metastatic potential in solid tumors via a neo-angiogenesis caused by vascular endothelial cell growth factors (VEGFs) induced by hypoxia inducible factor-1alpha (HIF-1alpha), the effects of hypoxia on human seminoma cell lines were examined in terms of
Eosinophilic pneumonia associated with bleomycin in a patient with mediastinal seminoma: a case report.
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BACKGROUND
Lung toxicities resulting from the chemotherapeutic agent bleomycin encompass a variety of pathological changes, including bronchiolitis obliterans organizing pneumonia, interstitial pneumonitis and progressive interstitial fibrosis. We report a rare case of eosinophilic pneumonia
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
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Hypoxia promotes stem cell maintenance and tumor progression, but it remains unclear how it regulates long-term adaptation toward these processes. We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ
Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors.
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Testicular germ cell tumors (TGCTs) represent a highly curable malignancy, however a small proportion of patients fails to be cured with cisplatin-based chemotherapy. Carbonic anhydrase IX (CA IX) is upregulated by hypoxia in several cancer types and correlates with a poor prognosis. The present
18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study.
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BACKGROUND
The usefulness of 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography (PET) has been investigated in thymic epithelial tumors. However, little is known about PET imaging of (18)F-FDG in primary non-thymic mediastinal neoplasms. The aim of this study is to explore
Low frequency of HIF-1α overexpression in germ cell tumors of the testis.
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Cellular hypoxia is a hallmark of cancer. Hypoxia-inducible factor-1α (HIF-1α) and von Hippel-Lindau protein (pVHL) are the key mediators of cellular response to hypoxia. Little is known about their role in germ cell tumors of the testis. We therefore examined their status in a cohort of germ cell
[Immediate results of hypoxiradiotherapy of malignant tumors].
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The paper represents a comparative analysis of hypoxiradiotherapy of 202 patients with malignant tumors of different sites. A significant decrease (a 3.5-fold) in the number of severe local radiation reactions was noted in hypoxiradiotherapy of cancer of the esophagus, pancreas and metastases of
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