Lingdancao granules, 4 packs per time (3g/pack), three times per day; analogous oseltamivir phosphate capsule, 1 capsule per time, twice per day.Drugs must be used on the day of fever and last for five days continuously.

Oseltamivir phosphate capsule (tamiflu), 1 capsule per time (75mg), twice per day; analogous Lingdancao granules, 4 packs per time, three times per day.Drugs must be used on the day of fever and last for five days continuously.

Analogous Lingdancao granules, 4 packs per time, three times per day, analogous oseltamivir phosphate capsule, 1 capsule per time, twice per day.Drugs must be used on the day of fever and last for five days continuously.

Influenza

4 packs per time (3g/pack), three times per day

Lingdancao granules

analogous oseltamivir phosphate capsule

Oseltamivir phosphate capsule

analogous Lingdancao granules

Lingdancao Granules in the Treatment of Seasonal Influenza

Randomized, Double-Blinded, Oseltamivir-and-Placebo-Controlled Clinical Study About Lingdancao Granules in the Treatment of Seasonal Influenza

fever,nasal obstruction, running nose, sore throat, cough, myalgia, fatigue, headache, aversion to cold and sweating

The time needed for defervescence from the first dose of study medication to the time when body temperature drop to normal (body temperature drop to 37.4℃ or below and is sustained for ≥24 hours)

aversion to cold, nasal congestion, muscle aches, sore throat, runny nose, fatigue, headache, cough, sweating

Time to return to normal states of health and activity. Return to normal status was defined as the time (in hours) from study drug initiation to the first 24-hour period in which participants returned to their normal state (work or school) and remained so for 24 hours.

defined as the time from the beginning of study medication to the first time the viral nucleic acid test was negative (negative for both virus culture and PCR, and continuing negative in subsequent virus detection).

Hongxia Ma

Professor

The First Affiliated Hospital of Guangzhou Medical University

Patients will be put on the standard dose of 150 mg/day of erlotinib. Patients will be entered into the study on different dose levels of theophylline (100 mg/bid, 150 mg/bid, 200 mg/bid, or 200 mg/tid) for 28 days to find what is the lowest dose that effectively controls the diarrhea caused by erlotinib.

Patients will be kept on a specified dose of theophylline while the dose of erlotinib increases in each group of patients enrolled (200 mg/qd, 225 mg/qd, or 250 mg/qd) for 28 days to determine what the maximum dose of erlotinib that can be given with theophylline and maintain a safety profile.

Non-small Cell Lung Cancer

Advanced Solid Malignancies

Theophylline

Erlotinib

Cross Cancer Institute

A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline

A Phase I, Single-center, Non-randomized, Open-label Study to Determine the Lowest Effective Theophylline Dose That Decreased Erlotinib's Diarrhea at the Standard Dose of 150 mg/Day and to Determine the Highest Erlotinib Dose in Combination With Theophylline That Can be Administered to Patients

Once the lowest effective dose of theophylline that will prevent or maximally ameliorate erlotinib's diarrhea at 150 mg/day taken daily for 28 days is determined, we will determine what is the highest dose of erlotinib that can be administered with theophylline that can be administered with an acceptable safety profile

AHS Cancer Control Alberta

Marinol

Placebo

Total

Sex: Female, Male

Region of Enrollment

Number of people still experiencing the same amount of chest pain during treatment than previously without

Frequency of Chest Pain Episodes

Total (intensity (0(none) - 3(severe) + duration (0(none) - 3(longer than 30 mins)) at end of 1 month treatment; higher represents worse outcome; the total score ranges from 0 to 6 and is the sum of the intensity and duration

Frequency of Chest Pain in Treatment Group vs Baseline

Intensity (0(none) - 3(severe)) at baseline vs 1 month for chest pain episodes; higher represents worse outcome; multiple chest pain totals are averaged

Intensity of Chest Pain Episodes

This is determined by the Esophageal Balloon Distension Test; range 0-65 mmHg

Sensory Thresholds for First Sensation

0 - is none and 3 is longer than 30 mins; higher values is worst outcome; chest pain totals are averaged

Duration of Chest Pain Episodes

When participants felt pain at earliest pressure; range 0-65 mmHg

Sensory Thresholds for Discomfort

When highest amount of pain was felt; range is 0-65 mmHg

theophylline/diarrhée

Lingdancao Granules in the Treatment of Seasonal Influenza

A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline

The Effects of Cannabinoid on Patients With Non-GERD Related Non Cardiac Chest Pain

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