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theophylline/fatigue
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Effects of theophylline on diaphragmatic strength and fatigue in patients with chronic obstructive pulmonary disease.
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We studied the effects of theophylline on diaphragmatic strength and fatigue in 15 patients with severe chronic obstructive pulmonary disease. Diaphragmatic strength was assessed by measurement of the transdiaphragmatic pressure generated at functional residual capacity during a maximal inspiratory
Effects of theophylline on canine diaphragmatic contractility and fatigue.
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To distinguish the effects of theophylline on respiratory muscle contractility from alterations in respiratory muscle interaction or blood flow, we examined in vitro contractile properties and fatigue of canine diaphragm in two series of experiments. In the first series, a 40-mg/kg aminophylline
Theophylline delays skeletal muscle fatigue during progressive exercise.
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In this study, 31P nuclear magnetic resonance spectroscopy (NMRS) was used to examine the effect of theophylline on human forearm muscle metabolism during progressive exercise. Six healthy men (37 +/- 14 yr of age) were assigned to either a control (CTRL) group (n = 3), or a theophylline treatment
The effect of theophylline on respiratory muscle contractility and fatigue.
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The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction
Dyspnea and diaphragmatic fatigue in patients with chronic obstructive pulmonary disease. Responses to theophylline.
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This study sought answers to 2 questions: (1) Is severe dyspnea to the point of exhaustion regularly accompanied by diaphragmatic fatigue in patients with moderately severe chronic obstructive pulmonary disease (COPD)? (2) When diaphragmatic fatigue occurs in such patients, does theophylline prevent
Theophylline, fatigue, and diaphragm contractility: cellular levels of 45Ca and cAMP.
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The relationship between variations in diaphragmatic contractility and corresponding changes in total tissue levels of 45Ca and adenosine 3',5'-cyclic monophosphate (cAMP) was examined. The contractile performance of perfused contracting rat diaphragms was manipulated with theophylline (10(-4) M),
Respiratory muscle failure: fatigue or weakness? The role of theophylline.
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Effects of theophylline on pharyngeal dilator and diaphragm muscle contractile properties.
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Theophylline alleviates central and obstructive apneas of prematurity, and may improve adult obstructive sleep apnea. One mechanism of action appears to be a stimulatory effect on the motor output to upper airway dilator muscles. The purpose of the present study was to determine whether theophylline
Theophylline minimally alters contractile properties of canine diaphragm in vitro.
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We examined the effects of theophylline on contractile properties and high-frequency fatigue of canine diaphragm in vitro. Eighteen diaphragm muscle bundles were obtained from 10 anesthetized dogs and equilibrated in oxygenated Krebs solution to 100, 200, or 300 mg/l theophylline. These bundles were
Comparison of once-daily evening versus morning sustained-release theophylline dosing for nocturnal asthma.
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Eight diurnally active (approximately 0730-1100 hr) adults (41-61 yr) suffering from nocturnal asthma volunteered for a double-blind, cross-over randomized study of a once-daily dosing (600-900 mg/24 hr) of Armophylline (Rorer s.a., France), a sustained-release theophylline given either at 0800 hr
The effects of theophylline and caffeine on the isolated rat diaphragm.
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It is a well known fact that theophylline enhances the force of diaphragmatic contraction and delays fatigue. The action of caffeine which is a methylxanthine analogue on skeletal muscle are complex. It was claimed in few studies that the caffeine was more effective on the diaphragmatic
Fatigue in frog skeletal muscle fibres and effects of methylxanthine derivatives.
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The influence of theophylline and the related drug caffeine on the mechanical performance of fatigued muscle fibre isolated from semitendinosus muscle of Rana temporaria (2.5-6.7 degrees C) was investigated. The fibre was stimulated supramaximally to produce I s fused tetani and 2 s and 10 s
Effect of methylxanthines on diaphragmatic fatigue in the piglet.
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Studies in adult animal and human subjects have suggested that the methylxanthine drugs can delay the onset or attenuate the severity of diaphragmatic fatigue. We have investigated the effect of aminophylline and caffeine on the pressure-generating capacity of the fatigued diaphragm in 1-mo-old
Theophylline: short term treatment.
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In this review article on short term-effects of theophylline, results of studies with single administration of theophylline are compiled, supplemented by several studies with a therapeutic administration up to 4 Days. Data at hand show limited to moderate bronchodilatator effect of theophylline,
Effect of theophylline on membrane potential and contractile force in hamster diaphragm muscle in vitro.
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Theophylline enhances the force of diaphragmatic contraction and delays fatigue. The mechanism is not known, but recent evidence suggests it may act at the cell membrane. To test this hypothesis, we studied the effect of theophylline on resting membrane potential and tension in hamster diaphragm
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