Loading dose 40mg/kg IV caffeine citrate, followed 12 hours later by 20mg/kg IV caffeine citrate, followed 12 hours later by 10mg/kg IV caffeine citrate, followed 12 hours later by 10mg/kg IV caffeine citrate.

Loading dose 20mg/kg IV caffeine citrate, followed 12 hours later with D5W placebo, followed 12 hours later with 10mg/kg IV caffeine citrate, followed 12 hours later with D5W placebo.

Loading dose 40mg/kg IV caffeine citrate, followed 12 hours later by 20mg/kg IV caffeine citrate, followed 12 hours later by 10mg/kg IV caffeine citrate, followed 12 hours later by 10mg/kg IV caffeine citrate.
Caffeine citrate: Caffeine to be administered as outlined to compare efficacy of different dosages.

High Dose Caffeine

Loading dose 20mg/kg IV caffeine citrate, followed 12 hours later with D5W placebo, followed 12 hours later with 10mg/kg IV caffeine citrate, followed 12 hours later with D5W placebo.
Caffeine citrate: Caffeine to be administered as outlined to compare efficacy of different dosages.

Standard Dose Caffeine

Total

Reported as weeks of gestational age at birth

Sex: Female, Male

Race (NIH/OMB)

Region of Enrollment

Apparent diffusion coefficient is a measure of microstructural maturation obtained from brain MRI.

White Matter Microstructural Maturation

Mortality Rates

Cerebellar Hemorrhage

Length of Time Requiring Invasive Respiratory Support

Defined as oxygen requirement at 36 weeks PMA

Rates of Chronic Lung Disease

Rates of Necrotizing Enterocolitis

Rates of Retinopathy of Prematurity

For the first 72 hours of life, infants were monitored for seizures using continuous limited channel aEEG. Seizures were defined as a series of sharp waves, at least ten seconds in duration, which evolve in frequency, amplitude, and morphology over time and are clearly distinguishable from the background or artifact.

Evaluation of EEG Seizure Burden

The Dubowitz Neurologic Examination is a standardized neurologic examination for infants at term age. It includes 6 compound optimality scores summed to obtain the total optimality score. Compound optimality scores include tone (range 0-10), tone pattern (range 0-5), reflexes (range 0-6), movements (range 0-3), abnormal signs (range 0-3), and behavior (range 0-7). The range for the compound optimality score is 0 - 34, with scores between 30.5 and 34 considered optimal and scores below 30.5 considered suboptimal.

Infant Neurobehavioral Scoring by Dubowitz Scale Prior to Discharge

The cognitive portion of the Bayley Scales of Infant Development assesses development in infants and toddlers between the ages of 0 and 3 years. Raw scores are converted to scale scores. A scale score of 100 is designed to represent the population mean. Scores below 100 represent developmental delay relative to the mean and scores above 100 represent advanced development relative to the mean.

Bayley Scales of Infant Development Cognitive Score at 2 Years of Age

Overall Study

Dr. Terrie Inder

Apnea of Prematurity

Intraventricular Hemorrhage

Brain Injury

Caffeine to be administered as outlined to compare efficacy of different dosages.

theophylline/hémorragie

MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine

NHLBI/NICHD Collaborative Studies of Asthma in Pregnancy

La base de données d'herbes médicinales la plus complète soutenue par la science