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theophylline/hémorragie
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A second case of infantile intracranial hemorrhage and severe neurological sequelae following theophylline overdose.
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Clopidogrel does not affect the pharmacokinetics of theophylline.
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The potential influence of clopidogrel on the pharmacokinetics of theophylline was evaluated in 15 healthy male subjects during the pharmacokinetic steady state of theophylline, after single and multiple doses. Theophylline was administered orally as one 300-mg capsule in the morning before
Use of the bleeding time in the neonatal intensive care unit.
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Impairments of primary hemostasis are frequently responsible for serious bleeding in sick infants in the neonatal intensive care unit (NICU). Therefore, a rational approach to these infants with hemorrhagic manifestations, in addition to an accurate medical history, a careful physical examination
Effects of theophylline administration and intracranial abnormalities on protective head turning response in preterm infants.
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OBJECTIVE
To determine effects of theophylline therapy for recurrent apnoea of prematurity and abnormal early (within the first 24 hours) cranial ultrasound abnormalities on protective neck turning response in preterm infants.
METHODS
A cross sectional descriptive study.
METHODS
The Neonatal Unit of
Phenobarbital increases the theophylline requirement of premature infants being treated for apnea.
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To determine the effect of phenobarbital sodium therapy and subependymal intraventricular hemorrhage (SEp-IVH) on the theophylline requirement of premature infants suffering with apnea and seizure activity, we compared three groups of patients as follows: group 1, those with apnea of prematurity
Effect of proxyphylline and benzopyrones on the cerebrocortical NAD/NADH redox state and reflectance in haemorrhagic shock.
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The effect of 7-(2-hydroxypropyl)theophylline (proxyphylline) and coumarin (Theokal) on cerebrocortical NAD/NADH redox state and vascular volume was investigated in cats in haemorrhagic shock. The influence of these drugs on cortical NADH and UV reflectance responses induced by nitrogen breathing
Comparison of Caffeine versus Theophylline for apnea of prematurity.
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Slow-release theophylline in pregnant asthmatics.
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OBJECTIVE
Oral theophylline treatment may be helpful in controlling severe asthma during pregnancy. This treatment, however, has been suspected of causing both complications and malformations. The objective of this investigation was to study the influence of theophylline treatment on the course of
Cerebral blood flow (CBF) autoregulation in spontaneously hypertensive rats (SHR) during chronic administration of a theophylline derivative (P-23).
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Chronic hypertension causes the lower and upper limits of CBF autoregulation to reset to higher blood pressure levels. In the present study we examined whether the theophylline derivative P-23, which had lowered blood pressure in SHR, would influence CBF autoregulation. P-23 (10 mg/kg po) was
Erythropoietin production in healthy volunteers subjected to controlled haemorrhage: evidence against a major role for adenosine.
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1. This study was carried out to assess the role of adenosine in the regulation of human erythropoietin (EPO) production. To this end we investigated in healthy volunteers whether the nonspecific adenosine antagonist theophylline increases and the adenosine uptake inhibitor dipyridamole decreases
The effect of prostacyclin (PGT2) on platelet behaviour. Thrombus formation in vivo and bleeding time.
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Prostacyclin (PGI2) infused intravenously into anaesthetized rabbits inhibited electrically-induced thrombus formation in the carotid artery, increased bleeding time and inhibited ex vivo platelet aggregation induced by ADP or arachidonic acid. The increase in bleeding time and the inhibition of ex
Induction of hepatic cytochrome P450s by the herbal medicine Sophora flavescens extract in rats: impact on the elimination of theophylline.
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The roots of Sophora flavescens (Sf) have been widely used as a herbal medicine for the treatment of diarrhea, gastrointestinal hemorrhage, and eczema. Cytochrome P450 (P450) forms including CYP1A2, CYP2B, CYP2E1, and CYP3A participate in the oxidative metabolism of theophylline, which is an
Histophatologic changes of lung in asthmatic male rats treated with hydro-alcoholic extract of Plantago major and theophylline.
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OBJECTIVE
Plantago major (P. major) is one of the medicinal crops in the world which has therapeutic properties for treatment of respiratory and gastrointestinal diseases. Theophylline is commonly used for the treatment of respiratory diseases. In this study, we investigated the protective effects
Severe hemorrhage attenuates cardiopulmonary chemoreflex control of regional sympathetic outputs via NTS adenosine receptors.
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Selective stimulation of inhibitory A1 and facilitatory A2a adenosine receptor subtypes located in the nucleus of the solitary tract (NTS) powerfully inhibits cardiopulmonary chemoreflex (CCR) control of regional sympathetic outputs via different mechanisms: direct inhibition of glutamate release
Comparative efficacy of hemodialysis and hemoperfusion in severe theophylline intoxication.
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OBJECTIVE
To determine the comparative efficacy of hemoperfusion and hemodialysis for severe theophylline toxicity in concurrent case series.
METHODS
A 10-year, prospective, observational study was performed of consecutive patients referred to a regional poison control center with severe
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