placebo identical to metformin.
placebo: placebo identical to metformin 2 tablets twice a day titrated from one table once a day. Participants remained on the maximum number of tolerated tablets (0,1,2,3,4).

Placebo

metformin 1000 mg twice a day
metformin: metformin 1000 mg twice a day titrated from 500 mg once a day.Participants remained on the maximum number of tolerated tablets (0,1,2,3,4).

Metformin

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

homozygous or heterozygous for APOE Epsilon 4

APOE Epsilon 4

Body Mass Index

Hemoglobin A1c

Fasting insulin

Systolic blood pressure

Total Cholesterol

High Density lipoprotein

The ADAS-cog is an aggregate for several cognitive tests intended to provide a global cognitive score and consists of 11 tasks. The tasks (and corresponding score range)) are Word Recall (0-10), Naming (0-4), Commands (0-5), Constructional Praxis (0-5) Ideational Praxis (0-5), Orientation (0-8), Word Recognition (0-12), Language (0-5), Word Finding Difficulty (0-5), and Remembering Test Instructions (1-5). The range of aggregate scores (sum of scores) is 1 to 69, with higher scores meaning worse cognitive performance.

Score of the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog)

The Selective Reminding Test measures verbal learning and delayed recall through a multiple-trial list-learning paradigm. Patients are presented aurally with a list of 12 words for trial 1 and are asked to recall as many as possible. For trials 2-6, there is a selective presentation of only those words not recalled on the previous trial. Trial 7 is similar to the other trials but is assessed after an 11-minute delay. The score for the selective reminding test is the unweighted average of seven individual study results (min=0 and max=84) Higher scores indicate a better cognitive performance.

Selective Reminding Test Total Recall score

Education in Years

The Selective Reminding Test measures verbal learning and delayed recall through a multiple-trial list-learning paradigm. Patients are presented aurally with a list of 12 words for trial 1 and are asked to recall as many as possible. For trials 2-6, there is a selective presentation of only those words not recalled on the previous trial. Trial 7 is similar to the other trials but is assessed after an 11-minute delay. The score for the selective reminding test is the unweighted average of seven individual study results (min=0 and max=84) Higher scores indicate a better cognitive performance. The total recall score from the first visit was subtracted from that of the last visit to calculate the change in score (total words recalled).

Placebo identical to metformin.
placebo: placebo identical to metformin 2 tablets twice a day titrated from one tablet once a day. Participants remained on the highest tolerated dose (0,1,2,3,4 tablets).

Metformin 1000 mg twice a day
metformin: metformin 1000 mg twice a day titrated from 500 mg once a day. Participants remained on the highest tolerated dose (0,1,2,3,4 tablets of 500 mg each).

Change in Total Recall Score in the Selective Reminding Test

The ADAS-cog is an aggregate for several cognitive tests intended to provide a global cognitive score and consists of 11 tasks. The tasks (and corresponding score range)) are Word Recall (0-10), Naming (0-4), Commands (0-5), Constructional Praxis (0-5) Ideational Praxis (0-5), Orientation (0-8), Word Recognition (0-12), Language (0-5), Word Finding Difficulty (0-5), and Remembering Test Instructions (1-5). The range of aggregate scores (sum of scores) is 1 to 69, with higher scores meaning worse cognitive performance. The change was calculated subtracting the baseline score from the final visit score.

placebo identical to metformin.
placebo: placebo identical to metformin 2 tablets twice a day titrated from one table once a day. Participants were maintained on the highest tolerated dose (0,1,2,3,4 tablets).

metformin 1000 mg twice a day
metformin: metformin 1000 mg twice a day titrated from 500 mg once a day.Participants were maintained on the highest tolerated dose (0,1,2,3,4 tablets of 500 mg each).

Change in Score of the Alzheimer's Disease Assessment Scale-cognitive Subscale (ADAS-cog)

Change in relative glucose uptake (rCMRgl) in the posterior cingulate-precuneus measured with subscale (ADAS-Cog) from brain [18]F-labeled 2-deoxy-2-fluoro-D-glucose (FDG) positron emission tomography (PET). The unit for rCMRgl is %. The results presented are absolute differences in rCMRgl, presented in % units; the change was calculated subtracting the baseline rCMRgl from the follow-up rCMRgl

Placebo identical to metformin.
placebo: placebo identical to metformin 2 tablets twice a day titrated from one table once a day. Participants remained on the highest tolerated dose (0,1,2,3,4 tablets).

Change in Relative Glucose Uptake (rCMRg) in the Posterior Cingulate-precuneus.

Change in plasma Amyloid beta-42 from baseline to 12 months

placebo identical to metformin.
placebo: placebo identical to metformin 2 tablets twice a day titrated from one table once a day. Participants remained on the highest tolerated dose (0,1,2,3,4 tablets).

metformin 1000 mg twice a day
metformin: metformin 1000 mg twice a day titrated from 500 mg once a day.Participants remained on the highest tolerated dose (0,1,2,3,4 tablets of 500 mg each).

Change in Plasma Amyloid Beta-42

placebo identical to metformin.
placebo: placebo identical to metformin 2 tablets twice a day titrated from one table once a day

metformin 1000 mg twice a day
metformin: metformin 1000 mg twice a day titrated from 500 mg once a day

Overall Study

Jose Luchsinger

Matching placebo
placebo: matching identical to metformin 2 tablets twice a day titrated from one table once a day

Mild Cognitive Impairment

Metformin 1000 mg twice a day titrated from 500 mg once a day

Placebo identical to metformin 2 tablets twice a day titrated from one table once a day

tics/œdème

Metformin in Amnestic Mild Cognitive Impairment

La base de données d'herbes médicinales la plus complète soutenue par la science