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Modulation of p,p'-DDT-induced tremor by catecholaminergic agents.
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p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; 75 mg/kg) or corn oil was administered po to male Fischer 344N rats. Tremor was quantified 8 hr later by spectral analysis of whole body movements. The effect of sc injection of pharmacological challenges on the spectral profile of body
Acute chlordecone toxicity in rats: a relationship between tremor and ATPase activities.
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Since we have demonstrated that ATPase system was sensitive to chlordecone, it was decided to examine the relationship between physiological and biochemical responses to this neurotoxin. Male Sprague-Dawley rats were fed with chlordecone by gastric intubation at 10, 25 and 50 mg/kg/day for three
Effects of prolonged tremor due to penitrem A in mice.
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Adult mice were given subcutaneous injections of purified penitrem A (10 mg/kg) dissolved in corn oil. The mycotoxin was prepared by ether extraction and absorption chromatography; identity was established by absorption and mass spectra. Tremors were sustained for 72 hr following a single dose;
Impact of chlorpyrifos on health biomarkers of broiler chicks.
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The present study aimed to investigate the deleterious effects of chlorpyrifos (CPF) in experimentally exposed broiler birds. The experiment was carried out on one day old (n = 120) broiler chicks. The CPF was reconstituted in corn oil as vehicle (1 ml/kg) to obtain a final concentration of a single
Evaluation of the developmental and reproductive toxicity of chlorpyrifos in the rat.
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Chlorpyrifos (O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothioate), an organophosphate insecticide, was evaluated for its potential to produce developmental and reproductive toxicity in rats following oral exposure. Pregnant Fischer 344 rats were given doses of 0 (corn oil vehicle), 0.1, 3.0,
[Mammalian toxicity of empenthrin (Vaporthrin, S-2852F)].
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1. Acute toxicity: Empenthrin ((RS)-(EZ)-1-ethynyl-2-methyl-2-pentenyl (1R)-cis/trans-chrysanthemate) caused some toxic signs such as muscular fibrillation, tremor, hypersensitivity, decrease of spontaneous activity, ataxic gait, lymb paralysis, irregular respiration, excretion of oily substance,
The influence of dosing volume on the toxicity of p,p'-DDT.
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In the IPCS Collaborative Study on Neurobehavioral Screening Methods, the "Top Dose" (TD) of p,p'-DDT (oral gavage, in corn oil) was determined to be different depending on the volume of administration: TD = 87 mg/kg when delivered in 1 ml/kg (i.e., 87 mg/ml) vs. TD = 130.5 mg/kg when given at 5
NTP Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60% m-Xylene, 14% p-Xylene, 9% o-Xylene, and 17% Ethylbenzene) (CAS No. 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
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The technical grade of xylenes (mixed) (hereafter termed xylenes) contains the three isomeric forms and ethylbenzene (percentage composition shown above). The annual production for 1985 was approximately 7.4 x 108 gallons. Xylenes is used as a solvent and a cleaning agent and as a degreaser and is a
Direct administration of chlordecone into Japanese quail eggs has persistent effects on conditioned behavior of adults.
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Chlordecone (0.1 to 10 mg) or corn oil vehicle was injected into Japanese quail eggs on day 1 of incubation. Higher doses (0.5-10 mg per egg) produced tremor and ataxia at hatching and dose-related decreases in hatchability and survivability. Doses lower than 0.25 mg per egg had no effects. Gonad
NTP toxicity studies of carisoprodol (CAS No. 78-44-4) administered by Gavage to F344/N rats and B6C3F1 mice.
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[carisoprodol structure: see text] Carisoprodol is a widely used skeletal muscle relaxant and analgesic and is available as a prescription drug. Comparative studies were conducted to determine the toxicity of carisoprodol administered in corn oil and in 0.5% methylcellulose by gavage. Carisoprodol
Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats.
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Published reports of status epilepticus due to intraperitoneal injection containing propylene glycol in rats are sparse. In fact, there are no reports specifying a maximum safe dose of propylene glycol through intraperitoneal administration. We report here a case of unexpected seizures in Sprague
Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.
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Neurotoxicity in the mouse was produced following oral administration of chlordecone at 10, 25 and 50 mg/kg/day in corn oil vehicle. Hyperexcitability and tremors were observed on the 1st, 4th and 9th day after the administration of chlordecone at 50, 25 and 10 mg/kg/day, respectively, and mortality
Ultrasound-induced epileptiform activity in rats treated with hexachlorobenzene.
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Hexachlorobenzene (HCB), an environmental contaminant, has caused spontaneous convulsions in infants and neonate rats born and breast-fed from exposed mothers as well as in weanling rats exposed for many weeks. This study aimed to determine if HCB causes epileptiform convulsions in adult rats. For
Neuropharmacologic and neuropathologic effect of fenvalerate in mice and rats.
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B6C3F1 mice and Sprague-Dawley rats displayed the characteristic signs of pyrethroid intoxication following single oral doses ranging from 56 to 320 and 133 to 1000 mg/kg fenvalerate, respectively. The LD50s for mice and rats were 180 and 776 mg/kg, respectively, with corn oil as the vehicle. Signs
Effects of oral exposure of synthetic pyrethroid, cypermethrin on the behavior of F1-progeny in mice.
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Cyermethrin, a type II synthetic pyrethroid insecticide, was evaluated through assessment of the behavioral development of F1-progeny of mice. Groups each of 30 male and 30 female ICR (CD-l) mice, as F0-generation, were given 0, 2.5, 5, and 10mg/kg/day cypermethrin in corn oil orally for 4 weeks/5
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