Intervention : Topical Melatonin(3%) at dosage of 15 mg once daily

Oral Leukoplakia

Topical melatonin at 3% concentration with dosage of 15 mg once daily will be applied on the lesion for 6 weeks followed by a follow up of 3 months

topical melatonin

Topical application of placebo once daily for 6 weeks with a follow up for 3 months

PLACEBO

Post graduate institute of dental sciences

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study

measurement of the lesion and scored according to RECIST criteria

Grading of dysplasia according to Speight classification (2007).

Percentage of a total number of Ki-67 positive cells to a total number of cells will be primarily deducted.

Postgraduate Institute of Dental Sciences Rohtak

TR- Subjects defined as having treatment resistant depression, who have failed at least 2 adequate trials of an antidepressant. Subjects will be treated in an open label trial for their depression, with the goal of sustained remission.

Major Depression

Dosage and drug types change based on patients need and response.
doxepin, clomipramine, amoxapine, amitriptyline, maprotiline, desipramine, nortriptyline, trimipramine, imipramine, protriptyline, isocarboxazid, phenelzine, tranylcypromine, moclobemide, fluvoxamine, paroxetine, fluoxetine, sertraline, citalopram, escitalopram, venlafaxine, atomoxetine, pramipexole, bromocriptine, quetiapine, clozapine, olanzapine, ziprasidone, aripiprazole, paliperidone, Risperidone, bupropion, mirtazapine, pindolol, topiramate, trazodone, Lithium,

Open label pharmacotherapy

University of Ottawa Institute of Mental Health research homepage

tryptophan/atrophie

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism

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