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Page 1 de 382 résultats
Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever.
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Large granular lymphocytes (LGL) with a T or natural killer (NK) lymphoblast morphology and indiscriminate (non-major histocompatibility complex-linked) cytotoxicity for a variety of target cells can be derived in culture from the tissues of animals infected with either alcelaphine herpesvirus-1
Involvement of tyrosine kinase in the pyrogenic fever exerted by NOS pathways in organum vasculosum laminae terminalis.
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Nitric oxide synthase (NOS) is an enzyme which has a distinct cytokine-inducible isoform (iNOS). Many cytokine receptors have an intracellular tyrosine kinase domain. Here we have used two tyrosine kinase inhibitors (genistein and lavendustin A) to investigate the potential role of tyrosine kinase
Comparision of a glutaraldehyde-modified pollen--tyrosine adsorbate with an alum-precipitated pollen vaccine in the treatment of hay fever.
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Nineteen patients with hay fever symptoms received nine weekly injections of pyridine-extracted alum-precipitated grass pollen vaccine (Alavac P). The results were compared with agroup of twenty patients who received a three injection series of a glutaraldehyde-modified pollen-tyrosine vaccine
A trial of hyposensitization in 1974/5 in the treatment of hay fever using glutaraldehyde-pollen-tyrosine adsorbate.
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One hundred patients with hay fever were treated in 1974/5 with a glutaraldehyde-pollen-tyrosine adsorbate, the response to treatment being assessed at the end of the hay fever season by direct questioning of the patient and examination of a daily record card. Successful results of treatment were
[Mechanism of enzymatic regulation of tyrosine turnover in hyperthermia].
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Activities of tyrosine aminotransferase and phenylalanine hydroxylase were studied in rat liver tissue in hyperthermia. Effects of heliothermic and laboratory chamber heating treatments were studied using intact animals and the rats preadministered with the enzyme substrates or hydrocortisone and
Severe toxicity of skin rash, fever and diarrhea associated with imatinib: case report and review of skin toxicities associated with tyrosine kinase inhibitors.
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Chronic myeloid leukemia (CML) is characterized by a Philadelphia chromosome which contains an oncogene, bcr-abl. This oncogene encodes a tyrosine kinase which is constitutively activated. Imatinib, a tyrosine kinase inhibitor (TKI), has been widely used in the treatment of CML. Dasatinib and
In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats.
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We measured the rectal temperature of free-moving, conscious rats after intracerebroventricular (i.c.v.) injections of lipopolysaccharide (LPS) and interleukin-1beta (IL-1beta) with or without various antagonists to investigate the mechanisms involved in LPS-induced fever. LPS (3 microg) elicited
Inactivation of wild-type BCR/ABL tyrosine kinase in hematopoietic cells by mild hyperthermia.
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Temperature-sensitive mutants of BCR/ABL tyrosine kinase have been extensively used to study the mechanisms of cell transformation and signal transduction. However, little is known about the effect of temperature on the activity of wild-type BCR/ABL gene product. In this study, we demonstrate that
Comparison of alum-precipitated aqueous extracts and modified ragweed tyrosine adsorbate vaccine in the treatment of ragweed hay fever.
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Thirty-five ragweed-sensitive patients received immunotherapy with either alum-precipitated aqueous extracts (AP) or modified ragweed tyrosine adsorbate vaccine (Pollinex-R). Symptoms decreased with AP therapy only. Immunologically, there was a blunted specific IgE response and little specific IgG
In vitro cytotoxic effect of tyrosine kinase inhibitor sunitinib malate alone and in combination with hyperthermia on breast adenocarcinoma MCF-7 cells.
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In this study, the in vitro cytotoxic effect of sunitinib malate alone and combination with hyperthermia was evaluated on MCF-7 cells (human breast adenocarcinoma cell line).
For this purpose cell proliferation assay, mitotic index and labelling index analysis among cell kinetic parameters were
Tyrosine prevents effects of hyperthermia on behavior and increases norepinephrine.
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Tyrosine (TYR) is the precursor of the catecholamine (CA) neurotransmitters, dopamine (DA) and norepinephrine (NE). Catecholamines, especially NE, participate in the response of the brain to acute stress. When animals are acutely stressed, NE neurons become more active and tyrosine availability may
[A new desensitization agent in the treatment of ragweed-induced seasonal allergic rhinitis (hay fever) in children: MRTA (modified ragweed tyrosine adsorbate)].
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Effects of p-chlorophenylalanine, alpha-methyl-p-tyrosine, morphine and chlorpromazine on prostaglandin E1 hyperthermia in the rabbit.
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EVIDENCE FOR DEVIATION IN THE METABOLISM OF TYROSINE IN RHEUMATIC FEVER. PRELIMINARY COMMUNICATION.
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[Tyrosine metabolism in patients with epidemic hemorrhagic fever with renal syndrome].
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