The present invention provides novel DNA constructs encoding high methionine zein proteins, the expression of which is not negatively regulated by the dzr1 regulatory protein. The constructs of the invention comprise a .delta.-zein coding region operably linked to a promoter and a 3' UTR which has been modified so as to be devoid of any binding sites for the dzr1 regulatory protein. Preferably, the entire 3' UTR is replaced by a heterologous sequence that does not contain any dzr1 binding sites. Transgenic corn plants comprising the DNA constructs of the invention are also provided. These plants consistently produce high methionine corn seeds.

Rutgers, The State University of New Jersey

Method for producing high methionine corn seeds

A liquid dual coated dosage formulation sustained release pharmaceutic having substantial shelf life prior to ingestion is disclosed. A dual coating is applied over controlled release cores to form dosage forms and the coatings comprise fats melting at less than approximately 101.degree. F. overcoated with cellulose acetate phthalate or zein. The dual coated dosage forms are dispersed in a sugar based acidic liquid carrier such as high fructose corn syrup and display a shelf life of up to approximately at least 45 days while still retaining their release profiles following ingestion. Cellulose acetate phthalate coated dosage form cores can in addition be dispersed in aqueous liquids of pH &lt;5.

zein/maïs

Method for producing high methionine corn seeds

Controlled release liquid dosage formulation

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