[Adaptation to periodic hypoxia restricts subdural hemorrhages in audiogenic epileptiform convulsions in rats].

A potent sound stimulation induces in Krushinskiĭ-Molodkina rats epileptiform seizures associated with increased blood levels of stressor hormones and subdural hemorrhages in the brain. Adaptation to periodic hypoxia carried out in a pressure chamber prolonged twofold the latent period of seizure development and blood hydrocortisone content after seizures. Such adaptation reduced the incidence of subdural hemorrhages and the mean size of these hemorrhages. Adaptation scheme used in our experiments is virtually the same as that clinically used at present in the management of patients with allergic diseases and neuroses.