[Prognostic factors of chronic glomerulonephritis and chronic non-inflammatory glomerulopathies rapid progression].

OBJECTIVE

To determine relationships between prognosis of rapid progression of chronic glomerulonephritis (CGN), chronic non-inflammatory glomerulopathies (CNG) with development of chronic renal failure and clinical, morphological types of the disease and tubulointerstitial component (TIC).

METHODS

137 CGN and CNG patients were followed up for 7 years. Favorable clinical types were found in 89, unfavorable ones in 48 patients. Favorable and unfavorable morphological types occurred in 87 and 50 patients, respectively. TIC was identified in 56 patients.

RESULTS

Rapid progression of CGN and CNG appeared to associate with the unfavorable clinical type (active nephritic types of CGN and nephrotic-hypertensive type of CNG), the unfavorable morphological type (mesangiocapillary glomerulonephritis and focal segmentary sclerosis/hyalinosis) and TIC.

CONCLUSIONS

Prognosis of rapid progression of CGN and CNG is most reliable in combination of the above three predictors or of the unfavorable clinical type with TIC.