[The determinations of tumor necrosis factor and interleukin 6 in serum of patients with sudden sensorineural hearing loss].

Serum level of tumor necrosis factor(TNF alpha) and interleukin 6(IL-6) were determined in 32 patients with sudden sensorineural hearing loss (SSHL), 15 patients with progressive sensorineural hearing loss(PSHL) and 20 normal controls by using enzyme-linked immunosorbent assay. The results showed that plasma TNF alpha and IL-6 levels in patients with SSHL were higher than those in PSHL group and in normal control group (P < 0.05). The study suggested that the TNF alpha and IL-6 played an important role in the pathogenesis of SSHL.