muscle weakness/athlasadh

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In the idiopathic inflammatory myopathies (IIM), do reactive oxygen species (ROS) contribute to muscle weakness?

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Logáil Isteach / Cláraigh

The idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune disorders, collectively known as myositis. Affected patients present with proximal muscle weakness, which usually improves following treatment with immunosuppressants, but often incompletely so, thus many patients remain

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.

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Logáil Isteach / Cláraigh

OBJECTIVE It is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes. However, it has been observed that there is a poor correlation between the suppression of inflammation and a recovery of muscle function in these

Skeletal muscle weakness caused by carrageenan-induced inflammation.

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Logáil Isteach / Cláraigh

BACKGROUND The skeletal muscle weakness associated with many chronic diseases has been attributed to the catabolic effect of pro-inflammatory cytokines. We aimed to determine if local muscle inflammation has direct affects on contractile function and contributes to muscle weakness independent of

Quantitative grip force assessment of muscular weakness in chronic inflammatory demyelinating polyneuropathy.

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Logáil Isteach / Cláraigh

In patients suffering from Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) disease severity is assessed by Medical Research Counsil (MRC) Scale or Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. However, none of these methods is appropriate to objectively

Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: results from the Amsterdam Osteoarthritis cohort.

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Logáil Isteach / Cláraigh

OBJECTIVE To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee

Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee.

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Logáil Isteach / Cláraigh

OBJECTIVE Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination

A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy.

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Logáil Isteach / Cláraigh

BACKGROUND The purpose of this case series was to quantify different strategies used to compensate in gait for hip muscle weakness. METHODS An instrumented gait analysis was performed of three females diagnosed with idiopathic inflammatory myopathies and compared to a healthy unimpaired subject.

Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness.

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Logáil Isteach / Cláraigh

Idiopathic inflammatory myopathies (IIMs) are a heterogenous group of complex muscle diseases of unknown etiology. These diseases are characterized by progressive muscle weakness and damage, together with involvement of other organ systems. It is generally believed that the autoimmune response

Differential diagnosis of idiopathic inflammatory myopathies in adults - the first step when approaching a patient with muscle weakness.

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Logáil Isteach / Cláraigh

Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle

Respiratory failure due to muscle weakness in inflammatory myopathies: maintenance therapy with home mechanical ventilation.

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Logáil Isteach / Cláraigh

Polymyositis and dermatomyositis are idiopathic inflammatory myopathies. Respiratory complications are a common feature, but ventilatory insufficiency is rare in these patients. We describe here three patients diagnosed with inflammatory myopathy (polymyositis) with respiratory failure due to muscle

The role of systemic inflammation in age-related muscle weakness and wasting.

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Logáil Isteach / Cláraigh

Ageing is associated with a slow, but progressive muscle weakness, which is largely attributable to muscle wasting. A diminished function of satellite cells at old age may hamper preservation and repair from (contraction)-induced injury and contribute to the age-related muscle wasting. Satellite

Inflammation-related muscle weakness and fatigue in geriatric patients.

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Logáil Isteach / Cláraigh

Inflammation in older persons is associated with muscle wasting, leading to frailty and functional decline. Most studies have focused on IL-6 and TNF-α. In order to further elucidate the underlying mechanisms of muscle wasting and reduced muscle mass and strength we investigated a large panel of

Induction of muscle weakness by local inflammation: an experimental animal model.

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Logáil Isteach / Cláraigh

OBJECTIVE The objective of this study was to characterize the response of skeletal muscle to a localized inflammation induced by the inflammatory agent casein. METHODS An inflammatory agent, casein, was injected into the right hindlimb and saline was injected into the left hindlimb of normal adult

GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness

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Logáil Isteach / Cláraigh

Growth differentiation factor 15 (GDF15) is a stress molecule produced in response to mitochondrial, metabolic and inflammatory stress with a number of beneficial effects on metabolism. However, at the level of skeletal muscle it is still unclear whether GDF15 is beneficial or detrimental. The aim

Rapamycin alleviates inflammation and muscle weakness, while altering the Treg/Th17 balance in a rat model of myasthenia gravis.

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Logáil Isteach / Cláraigh

Myasthenia gravis (MG) is an autoimmune disease commonly treated with immunosuppressants. We evaluated the novel immunosuppressant, rapamycin (RAPA), in a rat model of experimental autoimmune MG (EAMG). Mortality rates in the RAPA (12%) were significantly down compared with the EAMG (88%) or

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