7 torthaí
Patients with primary biliary cholangitis (PBC) with incomplete response to ursodeoxycholic acid are at risk of disease progression and need additional therapy. Obeticholic acid (OCA) was approved in Canada in May 2017, but its effectiveness in a real-world setting has not been described. We sought
Ochratoxin A (OcA) is a prominent member of a group of mycotoxins which display nephrotoxic, genotoxic, teratogenic, carcinogenic and immunosuppressive effects and which have also been linked to Balkan Endemic Nephropathy. The toxicity of OcA is thought to be primarily due to its inhibition of
BACKGROUND
Heart, kidneys, and liver are the vital organs present in vertebrates and some other animals. They have a wide range of functions, such as maintaining homeostasis, detoxification, protein synthesis, and production of biochemical, that are necessary for digestion and maintaining
The effects of aqueous extract of Hibiscus sabdariffa calyces on haematology and pathological changes in some selected organs during experimental Trypanosoma congolense infection of rats were investigated. Three groups of rats were intraperitoneally infected with T. congolense (Karu stock). One
OBJECTIVE
To investigate the influence of the use of oral hormonal contraceptive agents (OCA) on the biochemical indices related to metabolic zinc utilization and distribution, and to bone turnover in young adult women.
METHODS
Cross-sectional study. Blood and urine samples from non-users (-OCA;
The objective of this work is to study the biochemical effect in liver and kidney 2, 14, and 28 days after applying different tissue adhesives. In a prospective longitudinal study, 20 adult rats are assigned to two groups. After making incisions in the buccal mucosa, n-butyl-2-cyanoacrylate is
Objective- The objective of this study was to determine whether and how activation of farnesoid X receptor (FXR) by obeticholic acid (OCA), a clinical FXR agonist, modulates liver low-density lipoprotein receptor (LDLR) expression under normolipidemic conditions. Approach and Results- Administration