Provided herein are methods for treating pain such as acute or chronic pain or fever in subject without risking hepatotoxicity. The subject may be at risk of hepatotoxicity if administrated an acetaminophen monomer. The method includes administering a pharmaceutical composition containing an acetaminophen dimer compound, wherein the phenolic hydroxyl groups of two acetaminophen compounds are linked via an ethylene spacer.

OrphoMed, Inc.

ORPHOMED, INC.

Methods of treating pain or fever using pharmaceutically active acetaminophen dimers linked through phenolic hydroxyl groups

Phenolic polymers are prepared by oxidizing and polymerizing starting organic compounds comprising at least one hydroxyl group and at least one carbonyl group or at least two hydroxyl groups on an aromatic structure. One or more inorganic compounds or salts is added and the solution is allowed to stand at about 20.degree. C. to 80.degree. C. for a period of about at least 2 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solution. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural-product soil extracts. The materials are active hemorrhagic fever anti-viral agents, and are effective in anti-viral compositions for treating or preventing hemorrhagic fever viral diseases.

phenolic/fiabhras

Methods of treating pain or fever using pharmaceutically active acetaminophen dimers linked through phenolic hydroxyl groups

Synthetic soil-extract materials and medicaments for hemorrhagic fever viruses based thereon

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