Kaposi's Sarcoma Herpesvirus (KSHV) protease and assembly protein sequences are disclosed. Also disclosed are polynucleotides that encode the protease and assembly protein. The invention includes screening and detection methods, as well as KSHV protease inhibitory compositions.

The Regents of the University of California

Kaposi's Syndrome Herpesvirus protease and assembly protein compositions and methods

The present invention relates to the treatment of cancerous conditions in mammals by the administration to the site of disease compositions containing serine protease inhibitor. The cancerous conditions include osteocarcinomas, melanoma, Karopsi sarcoma and keratosis. The compositions are also useful to relieve the pain associated with the disease.

Alpha Med Pharmaceuticals Corp.

Treatment of osteocarcinoma with alpha-1--antitrypsin or secretory leucocyte protease inhibitor

Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumor cells that also express the putative tumor stem cell marker CD133. An antibody or antibody fragment such as 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumor cells and also as a therapeutic agent for treating cancers, tumors and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumor, renal tumor, prostate cancer, sarcoma and/or melanoma.

MONASH UNIVERSITY

MEMORIAL SLOAN-KETTERING CANCER CENTRE

LUDWIG INSTITUTE FOR CANCER RESEARCH LTD

Lackmann; Beate

Monash University

Memorial Sloan-Kettering Cancer Centre

Ludwig Institute for Cancer Research Ltd.

Anti-metalloprotease antibody for diagnosis and treatment of cancers

Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: ##STR1##wherein A is CH.sub.3 or NH.sub.2 ; X is a linear or branched C.sub.1 -C.sub.8 alkyl chain optionally containing hydroxy, amino and/or oxo groups; n is an integer from 1 to 6, and Sac is the residue of a mono-or oligo-saccharide, provided that when A is NH.sub.2 and X is -(CH.sub.2).sub.3 --CH(NH.sub.2)--C(=O)-, the monosaccharide residue is not substituted at the position 1, and n is an integer from 2 to 6 when Sac is the residue of an oligosaccharide, are useful as antiviral, particularly as antiretroviral, agents, and can be used either alone or together with other compounds used in AIDS treatment such as AZT and/or protease inhibitors, for the treatment of HIV-infection, AIDS and manifestations of AIDS such as Kaposi sarcoma. Particularly preferred compounds are aminoglycoside-arginine conjugates in which the saccharide is a natural aminoglycoside antibiotic such as kanamycin, gentamycin and neomycin that is conjugated to arginine residues.

Yeda Research and Development Co. Ltd.

Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds

sarcoma

protease

sarcoma/protease

Kaposi's Syndrome Herpesvirus protease and assembly protein compositions and methods

Treatment of osteocarcinoma with alpha-1--antitrypsin or secretory leucocyte protease inhibitor

Anti-metalloprotease antibody for diagnosis and treatment of cancers

Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds

An bunachar luibheanna míochaine is iomláine le tacaíocht ón eolaíocht