trolox/infarction

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Reduction of experimental myocardial infarct size by infusion of lactosylphenyl Trolox.

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Logáil Isteach / Cláraigh

OBJECTIVE The aim was to determine if lactosylphenyl Trolox could improve myocardial resistance to ischaemia and reperfusion. Lactosylphenyl Trolox is derived by coupling p-aminophenyl-beta-D-lactopyranoside to Trolox. Trolox, a polar analogue of vitamin E, has been found to protect human

Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction.

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Logáil Isteach / Cláraigh

Both Trolox (a water-soluble analogue of alpha-tocopherol) and ascorbic acid were more effective than superoxide dismutase or catalase in protecting myocyte cell cultures from free radical attack (induced by hypoxanthine and xanthine oxidase). In a canine model of two hours of left anterior

Neuroprotective effects of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in rats.

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Logáil Isteach / Cláraigh

OBJECTIVE In the present study, we have investigated the neuroprotective potential of 6hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), in middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia. METHODS Sprague-Dawley rats were subjected to 2 hours of MCAO followed by

Do antioxidant vitamins reduce infarct size following acute myocardial ischemia/reperfusion?

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Logáil Isteach / Cláraigh

There is controversy concerning the ability of antioxidant vitamins to reduce myocardial infarct size. We sought to determine whether a brief prophylactic treatment of vitamin C or vitamin C plus Trolox (a water-soluble form of vitamin E) could reduce myocardial infarct size in an experimental

Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: a case-control study in Italy.

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Logáil Isteach / Cláraigh

OBJECTIVE Oxidative processes have been related to atherosclerosis, but there is scanty information on the role of dietary antioxidants in the prevention of acute myocardial infarction (AMI). RESULTS The relationship between non-enzymatic antioxidant capacity (NEAC) and the risk of nonfatal AMI was

The effects of Trolox, a water-soluble vitamin E analogue, in regionally ischemic, reperfused porcine hearts.

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Logáil Isteach / Cláraigh

Myocardial protection by the water-soluble vitamin E analogue, Trolox, was investigated in 18 regionally ischemic, reperfused porcine hearts. The left anterior descending coronary artery was distally ligated for 45 min and was reperfused for three days. Five grams of Trolox (n = 9) were infused

Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction.

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Logáil Isteach / Cláraigh

In the current study, we compared purified Salvia miltiorrhiza extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant

[Plasma total anti-oxidant status in young survivors of myocardial infarction].

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Logáil Isteach / Cláraigh

Free oxygen radicals are involved in the endothelial lesion process which leads to the formation of the atheroma plaque and thrombosis. There is some evidence that antioxidant therapy may be beneficial in coronary heart disease prevention. Our objective was to study the plasma total anti-oxidant

Lymphocyte DNA damage in patients with acute coronary syndrome and its relationship with severity of acute coronary syndrome.

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Logáil Isteach / Cláraigh

OBJECTIVE The aim of this study was to investigate the association between lymphocyte DNA damage and acute coronary syndromes (ACS). METHODS The study population contained 53 patients with ACS, 48 patients with stable angina and 35 voluntary healty subjects. DNA damage was assessed by alkaline comed

Impact of marathon running on cardiac structure and function in recreational runners.

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Logáil Isteach / Cláraigh

The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35+/-10 years; height, 1.74+/-0.08 m; body mass,

Regenerative potential of mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells in infarcted myocardium.

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Logáil Isteach / Cláraigh

Pluripotent stem cell-derived cardiomyocytes (CMs) have become one of the most attractive cellular resources for cell-based therapy to rescue damaged cardiac tissue.

AIM

We investigated the regenerative potential of mouse embryonic stem cell

A water-soluble quaternary ammonium analog of alpha-tocopherol, that scavenges lipoperoxyl, superoxyl and hydroxyl radicals.

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Logáil Isteach / Cláraigh

The new water-soluble ammonium-analog of alpha-tocopherol (vitamin E) (compound 1: 3,4-dihydro-6-hydroxy-N,N, N-2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate) and its tertiary amine derivative (compound 2:

The antioxidant effects of Joongpoongtang 05 on brain injury after transient focal cerebral ischemia in rats.

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Logáil Isteach / Cláraigh

Traditional Korean medicines with antioxidant properties are believed to have potential therapeutic effects against oxidative stress in cerebral ischemia. In this study, the antioxidant effects of Joongpoongtang 05 (JP05) were evaluated in rat middle cerebral artery occlusion (MCAO). Male

Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals.

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Logáil Isteach / Cláraigh

To explore the role of neurotrophin-3 (NT-3) during cerebral ischemia, NT-3-deficient brains were subjected to transient focal ischemia. Conditional mutant brains produced undetectable amounts of NT-3 mRNA, whereas the expression of the neurotrophin, BDNF, the NT-3 receptor, TrkC, and the

H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene.

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Logáil Isteach / Cláraigh

BACKGROUND Heme oxygenase-1 (H(mox-1)) has been implicated in protection of cells against ischemia/reperfusion injury. RESULTS To examine the physiological role of H(mox-1), a line of heterozygous H(mox-1)-knockout mice was developed by targeted disruption of the mouse H(mox-1) gene. Transgene

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