The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.

AnGes MG, Inc.

Method of treating skin ulcers with vectors encoding hepatocyte growth factor

A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgical blood loss, acute nonvolemic hemodilutions, wounds, diabetic ulcers, chronic leg ulcers, pressure sores, tissue transplants, and sepsis. The compounds are capable of acting on hemoglobin in whole blood.

The Center for Innovative Technology

Allos Therapeutics, Inc.

Medical uses of allosteric hemoglobin modifier compounds in patient care

Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor--lot (HIF-1 .alpha.) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1.alpha. and asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.

Wu; Joseph C.

Huang; Mei

Giaccia; Amato J.

Chan; Denise

The Board of Trustees of the Leland Stanford Junior University

ShRNA gene therapy for treatment of ischemic heart disease

Methods and systems for treating a tissue with a high frequency electric field to activate MAPK/ERK pathways, induce angiogenesis, induce angionenic factos such as NO and VEGF, or promote wound healing. Aspects of the invention are directed to methods of treating chronic wounds such as diabetic ulcers and hypoxia induced wounds. Aspects utilize high frequency electric field having a frequency in the GHz range, and preferably between about 1 GHz and about 10 GHz.

University of Cincinnati

University Of Cincinnati

Method and device for treating a tissue with a high frequency electromagnetic field

ulcer

hypoxia

ulcer/hypoxia

Method of treating skin ulcers with vectors encoding hepatocyte growth factor

Medical uses of allosteric hemoglobin modifier compounds in patient care

ShRNA gene therapy for treatment of ischemic heart disease

Method and device for treating a tissue with a high frequency electromagnetic field

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