[Clinical significance of changes of lipid in elderly patients with hepatic schistosomiasis].

OBJECTIVE

To explore the clinical significance of lipid levels including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low density lipoprotein (LDL-C), and apolipoprotein (APOA I and APOB) of elderly patients with hepatic schistosomiasis.

METHODS

A total of 280 hospitalized elderly patients with hepatic schistosomiasis (198 cases of chronic liver fibrosis and 82 cases of hepatocirrhosis) were chosen as study objects, and their clinical data were collected and analyzed retrospectively. Meanwhile, the lipid levels between the patients with liver fibrosis and hepatocirrhosis, and those among the patients with A, B, C degrees of Child-pugh grading of liver function were compared.

RESULTS

Among the 280 patients, the abnormality rates of the lipid levels were 34.8%(69/198)and 100% (82/82) in the liver fibrosis group and hepatocirrhosis group respectively, and the difference between them were statistically significant (χ2 = 5.74, P < 0.05). The levels of TC, HDL-C, LDL-C, APOA I of the patients in the latter group were significantly lower than those in the former group (all P <0.05). The levels of TC, TG, HDL-C, APOA I, APOB of the patients with C degree liver function were significantly lower than those of the patients with A degree liver function, and the levels of TC, TG, HDL-C of the former were also lower than those of the patients with B degree liver function (all P <0.05).

CONCLUSIONS

The lipid levels of the elderly patients with hepatic schistosomiasis reduce obviously in the course of hepatocirrhosis, and it is correlated with the damage level of the liver. Lipid and apolipoprotein detections have certain values on the illness judgment and prognosis assessment.