Effect of Lantana camara toxicity on lipid peroxidation in guinea pig tissues.

Lantana intoxication of guinea pig inhibited lipid peroxidation in different tissues in the order: adrenals greater than liver greater than kidneys greater than heart greater than lungs greater than testes greater than brain. The inhibitory factor(s) appear to be present in the postmitochondrial fraction. Lantadene A, the toxic principle of lantana plant caused just marginal inhibition of lipid peroxidation in guinea pig liver homogenates. Bilirubin and fraction "p', a partially purified toxin of Lantana camara are more potent inhibitors of lipid peroxide formation. Lantana toxicity did not affect ascorbic acid, phospholipid content and superoxide dismutase activity of guinea pig liver. The enzyme activity of glutathione peroxidase was significantly elevated.