[The observation of the acute toxicity of the lanthanum and cerium to the buccal mucosa and systemic conditions of mice]

OBJECTIVE:The present study was to investigate the systemic and local acute toxicity of the lanthanum(La) and cerium(Ce) to the mice. METHODS: 0.2% and 1% La and Ce solutions were applied to buccal mucoa of mice.The systemic conditions and local histopathological changes were observed. RESULTS: The mice hadn't any systemic acute toxic reactions. Histological observation found that mucosal structures of most mice were almost normal,only a few mice showed the slight inflammation,but there were no significant differences between experimental and control groups. CONCLUSION: It was safe for local use of 0.2%,1% La and Ce to the buccal mucosa of mice. La and Ce may become a kind of safe caries-preventive drugs for local application.