Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (¹H, ¹³C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC₅₀ value of 0.06 and 0.60 μg/mL, respectively.

Keywords: Sesbania grandiflora L; 2-arylbenzofuran; cancer cell; sesbagrandiflorain D and E.