pyridine/कैनबिस

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पृष्ठ 1 से 22 परिणाम

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

The synthesis, SAR and binding affinities of cannabinoid-1 receptor (CB1R) inverse agonists based on furo[2,3-b]pyridine scaffolds are described. Food intake, mechanism specific efficacy, pharmacokinetic, and metabolic evaluation of several of these compounds indicate that they are effective orally

Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Peripherally restricted CB1 receptor inverse agonists hold potential as useful therapeutics to treat obesity and related metabolic diseases without causing undesired CNS-mediated adverse effects. We identified a series of tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and highly

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

As part of our efforts to develop CB2 PET imaging agents, we investigated 2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands. A total of 21 novel compounds were designed, synthesized, and evaluated for their potency and binding properties toward human and rodent CB1 and CB2.

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Despite the broad implications of the cannabinoid type 2 receptor (CB2) in neuroinflammatory processes, a suitable CB2-targeted probe is currently lacking in clinical routine. As part of our medicinal chemistry program, we have recently identified the pyridine-based CB2 PET radioligand

Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

The cannabinoid type 2 receptor has emerged as valuable target for therapy and imaging of immune- mediated pathologies. With the aim to find a suitable radiofluorinated analogue of the previously reported CB2 PET radioligand [¹¹C]RSR-056, 38 fluorinated derivatives were synthesized and

Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Recent developments indicate that CB(2) receptor ligands have the potential to become therapeutically important. To explore this potential, it is necessary to develop compounds with high affinity for the CB(2) receptor. Very recently, we have identified the oxazinoquinoline carboxamides as a novel

Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Male Wistar rats were trained to discriminate (-)-nicotine (0.4 mg/kg) from saline under a two-lever, fixed-ratio 10 schedule of water reinforcement. During test sessions the following drugs were coadministered with saline (substitution studies) or nicotine (0.025-0.4 mg/kg; combination studies):

Identification and analytical characterization of four synthetic cannabinoids ADB-BICA, NNL-1, NNL-2, and PPA(N)-2201.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Since the first appearance as psychotropic drugs in illegal markets in 2008, the spread of synthetic cannabinoids is becoming a serious problem in many countries. This paper reports on the analytical properties and structure elucidation of four cannabimimetic derivatives in seized material:

Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

This study was undertaken to analyze the involvement of periaqueductal gray (PAG) cannabinoid or group I metabotropic glutamate receptors in the formalin-induced changes on the rostral ventromedial medulla (RVM) ON- and OFF-cells activities. S.c. injection of formalin into the hind paw produced a

Prospective therapeutic agents for obesity: molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Presently, obesity is one of the major health problems in the developed as well as developing countries due to lack of physical work and increasing sedentary life style. Endocannabinoid system (ECS) and especially cannabinoid 1 (CB1) receptor play a key role in energy homeostasis. Food intake and

Can A Recently Developed Pig Model Be Used for In Vivo Metabolism Studies of 7-Azaindole Derived Synthetic Cannabinoids? A Study Using 5F-MDMB-P7AICA

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

New psychoactive substances (NPS), especially synthetic cannabinoids (SC) remain a public health concern. Due to ethical reasons, systematic controlled human studies to elucidate their toxicodynamics and/or toxicokinetics are usually not possible. However, such knowledge is necessary, for example,

In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

The metabolism and excretion of taranabant (MK-0364, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2{[5-(trifluoromethyl)pyridine-2-yl]oxy}propanamide), a potent cannabinoid-1 receptor inverse agonist, were evaluated in rats and rhesus monkeys. Following administration of

Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Ten new delta6a,10a-THC analogs with arylalkyl side chains, one with a dimethylaminoalkyl side chain, and six heterocyclic delta6a,10a-THC analogs [8-substituted 5,5-dimethyl-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzo-pyrano[4,3-c]pyridines] were prepared. They showed pharmacological

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Herbal & Natural Medicine

विज्ञान द्वारा समर्थित सबसे पूर्ण औषधीय जड़ी बूटी डेटाबेस

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विज्ञान द्वारा समर्थित हर्बल इलाज
छवि द्वारा जड़ी बूटी की मान्यता
इंटरएक्टिव जीपीएस नक्शा - स्थान पर टैग जड़ी बूटियों (जल्द ही आ रहा है)
अपनी खोज से संबंधित वैज्ञानिक प्रकाशन पढ़ें
उनके प्रभाव से औषधीय जड़ी बूटियों की खोज करें
अपने हितों को व्यवस्थित करें और समाचार अनुसंधान, नैदानिक परीक्षणों और पेटेंट के साथ अद्यतित रहें

एक लक्षण या बीमारी टाइप करें और जड़ी-बूटियों के बारे में पढ़ें जो मदद कर सकती हैं, एक जड़ी बूटी टाइप करें और बीमारियों और लक्षणों को देखें जिनके खिलाफ इसका उपयोग किया जाता है।
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