shikonin/परिगलन

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पृष्ठ 1 से 40 परिणाम

Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Tumor necrosis factor alpha (TNF-alpha) contributes to the pathogenesis of both acute and chronic inflammatory diseases and has been a target for the development of new anti-inflammatory drugs. Shikonins, the naphthoquinone pigments present in the root tissues of Lithospermum erythrorhizon Sieb. et

Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

An alternative cell demise programmed necrosis has also been proposed when apoptotic machinery is impaired or blocked during tumor necrosis factor alpha (TNFα) stimulation. Shikonin (SKN), an herbal extract from the Chinese plant, has been reported to induce either apoptosis or necrosis depending on

Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

The effects of shikonin on gastric cancer cells were investigated in this study. Exposure to shikonin reduced the viability of gastric cancer cells in a time- and dose-dependent manner. However, apoptosis was not observed in gastric cancer cell treatment with different concentrations of shikonin for

Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Shikonin, a natural naphthoquinone pigment isolated from Lithospermum erythrorhizon, has been reported to suppress growth of various cancer cells. This study was aimed to investigate whether this chemical could also inhibit cell growth of lung cancer cells and, if so, works via what molecular

Inhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

We previously developed a gene-gun-based in vivo screening system and identified shikonin as a potent suppressor of tumor necrosis factor-alpha (TNF-alpha) gene expression. Here, we show that shikonin selectively inhibits the expression of TNF-alpha at the RNA splicing level. Treatment of

Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Shikonin, which is derived from Lithospermum erythrorhizon, a herb used in traditional medicine, has long been considered to be a useful treatment for various diseases in traditional oriental medicine. Shikonin has recently been reported to have several pharmacological properties, e.g., it has

Anti-inflammatory effects of shikonin in human periodontal ligament cells.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

BACKGROUND Shikonin (SHI), an active component extracted from Radix Arnebiae, has been reported to possess anti-inflammatory properties in various cells. However, its effect on lipopolysaccharide (LPS)-stimulated human periodontal ligament cells (hPDLCs) is unknown. OBJECTIVE To investigate the

Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Angiogenesis is critical for tumor growth and inflammation. Shiunko is a Chinese herbal ointment used for the treatment of burns in Japan. Its main ingredient is the root of Lithospermum erythrorhizon, which had been used for treating tumors and inflammation in China since the 5th century. We report

Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Over the last few decades, food allergy (FA) has become a common disease in infants in advanced countries. However, anti-allergic medicines available in the market have no effect on FA, and consequently effective drug therapies for FA are not yet available. We have already demonstrated that mucosal

Non-cytotoxic doses of shikonin inhibit lipopolysaccharide-induced TNF-α expression via activation of the AMP-activated protein kinase signaling pathway

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Shikonin has been reported to exhibit a wide variety of medical functions. However, the strong non-selective cytotoxicity of shikonin can restrict its clinical application. The aim of the present study was to investigate the effects of shikonin at non-cytotoxic doses on the pro-inflammation

Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-κB signaling pathways.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

To study the anti-inflammation effect of Shikonin (Shik) and its mechanism, murine macrophage-like RAW264.7 cells (RAW264.7 cells) were divided into control group, LPS group (0.125, 0.25 and 0.5μg/ml), LPS (0.125, 0.25 and 0.5μg/ml) plus Shik (0.5, 1 and 2μM) group, and Shik (2μM) group. After

Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide (LSP)-stimulated BV2 microglial cells. Shikonin

Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury. Here we investigated the effects of

[Antitumor effect research progress of shikonin and its derivatives].

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Shikonin, the main active ingredient of Lithospermum, and its derivatives have been proved to have antitumor effects, and the anti-tumor mechanisms involve multiple targets. Based on recent literatures, this review focuses on the antitumor effects and its mechanisms. More emphases are given on the

Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications.

केवल पंजीकृत उपयोगकर्ता ही लेखों का अनुवाद कर सकते हैं

साइन अप करने के लिए लॉग इन करें

Microglial cells are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). During pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of

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Herbal & Natural Medicine

विज्ञान द्वारा समर्थित सबसे पूर्ण औषधीय जड़ी बूटी डेटाबेस

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उनके प्रभाव से औषधीय जड़ी बूटियों की खोज करें
अपने हितों को व्यवस्थित करें और समाचार अनुसंधान, नैदानिक परीक्षणों और पेटेंट के साथ अद्यतित रहें

एक लक्षण या बीमारी टाइप करें और जड़ी-बूटियों के बारे में पढ़ें जो मदद कर सकती हैं, एक जड़ी बूटी टाइप करें और बीमारियों और लक्षणों को देखें जिनके खिलाफ इसका उपयोग किया जाता है।
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