Molecular Nutrition and Food Research 2019-Nov
Apigenin Reverses Interleukin-1β-induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes.
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METHODS AND RESULTS
Apg protected cAMP-induced browning from IL-1β in primary human adipocytes as evidenced by increased expression of brown-specific markers, mitochondrial content, and respiratory function. Apg significantly repressed inflammatory markers and NF-κB activation induced by IL-1β in these adipocytes. Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1β treatment. Conversely, COX2 pharmacological inhibition or RNA silencing attenuated the positive effect of Apg on adipocyte browning in IL-1β treated cells. Additionally, blockage of PGE2 receptor 4 (EP4) attenuated Apg-mediated adipocyte browning. The effect of Apg on adipocyte browning in IL-1β-treated adipocytes was accompanied by an elevation in intracellular Ca2+ , partly due to TRPV1/4 receptor activation.