Bioorganic and Medicinal Chemistry Letters 2018-02
New lignans attenuating cognitive deterioration of Aβ transgenic flies discovered in Acorus tatarinowii.
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Five new lignan racemates, (±)-tatarinoid D-H (1-5), and three known analogues (6-8) were isolated from the rhizomes of Acorus tatarinowii. Their structures were established by 1D, 2D-NMR, HR-MS, IR and optical spectral data. Among them, 1 and 6-8 can alleviate the cognitive deterioration of Aβ transgenic flies.
