Clinical Cancer Research 2018-Sep
No Sugar Added: A New Strategy to Inhibit Glioblastoma Receptor Tyrosine Kinases.
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A novel inhibitor of N-linked glycosylation (NGI-1) inhibits the glycosylation and phosphorylation of multiple receptor tyrosine kinases in glioblastoma (GBM). NGI-1 sensitizes multiple models of GBM to chemotherapy and radiation in vitro and in vivo and may be especially effective in GBMs that retain active PTEN. Clin Cancer Res; 1-2. ©2018 AACR. See related article by Baro et al.
