Potential anti-inflammation nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera.
Ključne riječi
Sažetak
The studies on Stauntonia brachyanthera led to the isolations of 7 normal and nor-oleanane triterpenoids, including 2 new ones. Compounds 1 and 3 showed moderate inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with the IC50 values of 16.09 and 20.19 μM, respectively, which were stronger than that of positive control. A primary structure-activity relationship was also discussed, which revealed the anti-inflammation abilities of three types triterpenoids and their potential possibilities as the candidate compounds for the treatment of inflammation.