Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 2001-Jan

[Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats].

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M X Sheng

J Z Li

H Y Wang

ČLANAK: 12577378

BioSeek: 12577378

Ključne riječi

ishemija

oligurija

kozlinac

angelica

antifungik

Sažetak

OBJECTIVE

To observe the effect of Astragalus and Angelica on acute renal injury.

METHODS

Using the ischemia/reperfusion model established by blocking blood flow through clamping of bilateral renal artery for 45 min, the changes of glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa), urinary volume (UV) and mean arterial pressure (MAP) as well as the morphological change of kidney before and after ischemia/reperfusion were observed.

RESULTS

Astragalus and Angelica could promote recovery of RPF and GFR after ischemia/reperfusion, prevent the oliguria or shorten the oliguria period, reduce the increment of FENa and improve the histomorphological injury of kidney.

CONCLUSIONS

Astragalus and Angelica have certain effect in protecting kidney from acute renal injury.