acetophenone/pretilost

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Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors.

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Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in muscle and liver as well as resistance to

Inhibitory effects of stilbene derivatives from Parthenocissus tricuspidata on adipocyte differentiation and pancreatic lipase.

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Obesity, which is characterized by excessive fat accumulation, occurs by fat absorption by lipase and sequential fat accumulation in adipocytes through adipocyte differentiation. Thus, inhibition of pancreatic lipase activity and adipocyte differentiation would be crucial for the prevention and

In Silico Molecular Docking And Adme Studies Of 1,3,4-Thiadiazole Derivatives In Relation To In Vitro Pon1 Activity.

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BACKGROUND Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification. OBJECTIVE Based on antioxidative properties of PON1 and widely usage of 1,3,4-thiadiazole derivatives in pharmaceutical,

Cynanchum bungei Decne and its two related species for "Baishouwu": A review on traditional uses, phytochemistry, and pharmacological activities.

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Cynanchum bungei Decne. (CB) (Asclepiadaceae) and its two related species Cynanchum auriculatum Royle ex Wight. (CA) and Cynanchum wilfordii (Maxim.) Hemsl. (CW) are well known Chinese herbal medicines known by the name Baishouwu. Among them, CB has long been used for nourishing the

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