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Stranica 1 iz 26 rezultatima
A large-scale mutagenesis screen to identify seizure-resistant zebrafish.
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OBJECTIVE
Zebrafish are a vertebrate organism ideally suited to mutagenesis screening strategies. Although a genetic basis for seizure susceptibility and epilepsy is well established, no efforts have been made to study seizure resistance. Here we describe a novel strategy to isolate
Thallium toxicosis in a dog consequent to ingestion of Mycoplasma agar plates.
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A 1-year-old dog ingested a mixture of blood agar and Mycoplasma agar plates. The Mycoplasma agar plates contained thallium acetate, which resulted in an estimated minimum dose of 5 mg thallium acetate/kg bodyweight. Clinical signs over the course of 2-3 weeks included vomiting, diarrhea, weight
Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.
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Disruption of E3 ubiquitin ligase activity in immature zebrafish mind bomb mutants leads to a failure in Notch signaling, excessive numbers of neurons, and depletion of neural progenitor cells. This neurogenic phenotype is associated with defects in neural patterning and brain development. Because
In vitro/in vivo evaluation of agar nanospheres for pulmonary delivery of bupropion HCl.
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Bupropion HCl is an atypical antidepressant drug with rapid and high first-pass metabolism. Sustained release dosage form of this drug is suggested for reducing its side effects which are mainly seizures. The aim of the present study was to design pulmonary agar nanospheres of bupropion HCl with
Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design.
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Bupropion is an atypical antidepressant drug. Fluctuating in its serum levels following oral administration of immediate release dosage forms leads to occasional seizure. The aim of the present work was designing of sustained release bupropion HCl nanospheres suited for pulmonary delivery. Agar
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
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BACKGROUND
Epilepsy affects around 1% of people, but existing antiepileptic drugs (AEDs) only offer symptomatic relief and are ineffective in approximately 30% of patients. Hence, new AEDs are sorely needed. However, a major bottleneck is the low-throughput nature of early-stage AED screens in
The first Korean case of candidemia due to Candida dubliniensis.
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Candidemia due to uncommon Candida spp. appears to be increasing in incidence. C. dubliniensis has been increasingly recovered from individuals not infected with HIV. Identification of C. dubliniensis can be problematic in routine clinical practice due to its phenotypic resemblance to C. albicans.
A loss of GABAergic hippocampus innervation in rats with cobalt-induced epilepsy demonstrated by Wolman's fluorescence method.
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The topohistochemistry of gamma-aminobutyric acid (GABA) was studied in the hippocampus of rats with epileptiform activity provoked by cortical implantation of cobalt-agar pellets and in control rats with implanted agar-pellets. Using the GABA specific fluorochroming procedure of Wolman (1971) a
Microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy.
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BACKGROUND
Cultural means of pediatric treatment during ill health is a mainstay in Africa, and though urine has been known to contain enteric pathogens, urine therapy is still culturally applicable in some health conditions and also advocated as alternative therapy. The study therefore, is to
[Antibiotic activity of cortalcerone and its 7-diphenylhydrazone derivative].
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The present paper investigates the antibiotic properties of the novel antifungal antibiotic agent cortalceron and its semisynthetic derivative cortalceron 7-diphenylhydrazone. The MIC values were assayed by the agar diffusion method. Cortalceron was found to weakly inhibit the growth of E. coli and
[Effect of diucifon and its structural precursors on inflammatory and pain reactions].
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The anti-inflammatory and analgesic action of diucifon, methyluracil and 4,4'-diaminodiphenylsulfone (DDS) was studied in comparison with some nonsteroid preparations. In three traditional models of agar, kaolin and carrageenan paw edema and in the models of analgesia (convulsions, induced by
Primary amoebic meningoencephalitis due to Naegleria fowleri.
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Primary amoebic meningoencephalitis (PAM) due to Naegleria fowleri was detected in a 36-year-old, Indian countryman who had a history of taking bath in the village pond. He was admitted in a semi comatosed condition with severe frontal headache, neck stiffness, intermittent fever, nausea, vomiting,
MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS).
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A 3-yr-old female spayed grizzly bear (Ursus arctos horribilis) was evaluated for seizure activity along with lethargy, inappetence, dull mentation, and aggressive behavior. Magnetic resonance (MR) examination of the brain revealed a contrast-enhanced right cerebellar mass with multifocal smaller
Disseminated zygomycosis due to Rhizopus schipperae after heatstroke.
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A 21-year-old woman suffered heatstroke and developed diarrhea while trekking across south Texas. The heatstroke was complicated by seizures, rhabdomyolysis, pneumonia, renal failure, and disseminated intravascular coagulation. The patient's stool and blood cultures grew Campylobacter jejuni. The
Selected Microbiological and Chemical Characteristics of Illegally Produced and Marketed Soft Hispanic-Style Cheeses in California.
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Recently, there has been a great concern among California state health authorities and the dairy industry that large volumes of illegally produced Hispanic-style cheeses find their way into local markets. In cooperation with the State Milk and Dairy Foods Control Branch, California Department of
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