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8 rezultatima
Bisarylimidazolyl fatty acid amide hydrolase inhibitors
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FIELD OF THE INVENTION
The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase and are useful for the treatment of conditions affected by inhibiting fatty acid amide
Aromatic amides of heterocyclic compounds and therapeutic compositions containing same
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SUMMARY OF THE INVENTION
According to our invention, in its broadest aspect, we provide a compound corresponding to the general formula (I): ##STR1## in which: R is a lower (C.sub.1 -C.sub.6) alkoxy or alkenoxy;
R.sub.1 and R.sub.2, which may be the same or different, are selected from hydrogen,
Derivatives of amide analogs of certain methano bridged quinolizines
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This invention relates to novel amide derivatives of certain 2,6-methano-2H-quinolizines-type compounds, to the intermediates and processes for their preparation, to their ability to antagonize the effects of serotonin at the 5HT.sub.3 receptors, and to their end-use application in the treatment of
N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists
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This application is a 371 of PCT/GB93/02130, Oct. 14, 1993.
This invention relates to novel compounds having pharmacological activity, to a process for their preparation and to their use as pharmaceuticals.
European Journal of Pharmacology 146 (1988 ), 187-188, and Naunyn-Schmiedeberg's Arch.
Cannabimimetic lipid amides as useful medications
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BACKGROUND OF THE INVENTION
Classical cannabinoids such as the marijuana derived cannabinoid .DELTA..sup.9-tetrahydrocannabinol, (.DELTA..sup.9-THC) produce their pharmacological effects through interaction with specific cannabinoid receptors in the body. So far, two cannabinoid receptors have been
Piperidine derivative
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SUMMARY OF THE INVENTION
According to one aspect of our invention, we provide compounds of the general formula ##STR1## wherein R represents a halogen atom or a hydroxy, lower alkoxy, lower alkenyloxy, lower alkynyloxy or aralkyloxy (preferably a phenyl(lower)alkyloxy, e.g. benzyloxy) group, or a
5,6-dihydro-N-[(imidazol-4(or 5)-yl)methyl]-4H-pyrrolo[3,2,1-IJ]quinoline-1-carboxamides having 5-HT.sub. antagonist activity
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Prijava Registriraj se
This invention relates to amide derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their medical use.
In particular the invention relates to compounds which are potent and selective antagonists of 5-hydroxytryptamine (5-HT) at 5-HT receptors of the
Anti-psychotic (cycloalkenylalkylpiperidino) benzamides
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SUMMARY OF THE INVENTION
According to one aspect of our invention, we provide compounds of the general formula ##STR1## wherein R represents a lower alkoxy or lower alkenyloxy group; R.sup.1 and R.sup.2, which may be the same or different, each represent a hydrogen or halogen atom, or a
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