TECHNICAL FIELD
The present invention relates to an indole amide compound of Formula (1), a pharmaceutically acceptable salt or isomer thereof, and a composition and a method of preparing a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases comprising
FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF, or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein. TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
BACKGROUND OF THE INVENTION
The present invention relates to a method of reducing levels of TNF.alpha. and inhibiting phosphodiesterase in a mammal and to compounds and compositions useful therein.
TNF.alpha., or rumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear
INTRODUCTION
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor-.kappa.B (NF-.kappa.B)
INTRODUCTION
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor .kappa.B (NF-.kappa.B)
INTRODUCTION
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor .kappa.B (NF-.kappa.B)
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor .kappa.B (NF-.kappa.B) activation,
FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
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