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angiotensin/moždani udar
Veza se sprema u međuspremnik
Stranica 1 iz 27 rezultatima
Methods and compositions for the delayed treatment of stroke
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jan. 15, 2015, is named 2009912-0127_SL.txt and is 11,553 bytes in size.
BACKGROUND
Proper
Substituted triazoles as angiotensin II inhibitors
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FIELD OF THE INVENTION
This invention relates to novel compounds of the following formulae: ##STR1##
The invention also relates to pharmaceutical compositions comprising a compound of the invention as the active ingredient, a method of treating a physiological condition in mammals that is mediated
Use of inhibitors of the renin-angiotensin system
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FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorized into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
Active low molecular weight variants of angiotensin converting enzyme 2 (ACE2)
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BACKGROUND
The field of the invention relates to angiotensin converting enzyme 2 (ACE2) and variants of ACE2 for reducing plasma levels of Angiotensin II (1-8) and/or for increasing plasma levels of Angiotensin (1-7) in a subject in need thereof. The disclosed variants of ACE2 may include fragments
Use of inhibitors of the renin-angiotensin system
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FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorised into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
Use of inhibitors of the renin-angiotensin system
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FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorised into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
Use of inhibitors of the renin-angiotensin system
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FIELD OF THE INVENTION
This invention relates to the use of inhibitors of the renin-angiotensin system.
BACKGROUND OF THE INVENTION
Wasting diseases may be categorised into generalised and localised wasting diseases. To deal first with generalised wasting, many disease processes can lead to
Fused heterocyclic compounds, having angiotensin II antagonistic activity
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FIELD OF THE INVENTION
The present invention relates to novel fused heterocyclic compounds having potent pharmacological actions and intermediates for the preparation thereof. More particularly, the present invention relates to fused heterocyclic compounds having potent anti-hypertensive activity
Substituted N-biphenylyl lactams
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FIELD OF THE INVENTION
This invention relates to novel compounds of the following formula ##STR1## wherein B is a bisfused radical of the following formula ##STR2##
The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological
Biphenylmethane derivatives and pharmaceuticals containing the same
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This application is a continuation-in-part of PCT/JP93/01134 filed Aug. 11, 1993.
FIELD OF THE INVENTION
The present invention relates to novel biphenylmethane derivatives and salts thereof, said derivatives and salts having a potent angiotensin II antagonist activity and also having a powerful
Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof
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SUMMARY OF THE INVENTION
The present invention provides pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl[benzimidazole-7-carboxylat e having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which are of practical value in clinical use as therapeutic
Benzimidazole derivative compositions and medical use thereof
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SUMMARY OF THE INVENTION
The present invention provides 1-acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which is of practical value in clinical use as
1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-c arboxylate and compositions and methods of pharmaceutical use thereof
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SUMMARY OF THE INVENTION
In a first aspect of the invention there is provided 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate, including certain stable forms as well as pharmaceutically acceptable salts, which have
Potent
Cyclic compounds and their use
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FIELD OF THE INVENTION
The present invention relates to novel cyclic compounds having excellent pharmacological actions, their intermediates for the synthesis and salts thereof.
More specifically, the present invention relates to a compound represented by the general formula ##STR2## [wherein
Piperidine derivatives, their production and use
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TECHNICAL FIELD
This invention relates to novel piperidines derivatives which are of value as a pharmaceutical.
BACKGROUND ART
Although there have been known various compounds exhibiting inhibitory activity on angiotensin converting enzyme, any compound with such activity having a moiety of
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