After randomization, 60 subjects will receive oral dexlansoprazole (Dexilant 60 mg, Takeda Co. Ltd, Tokyo, Japan) once daily before breakfast for 8 weeks. Subjects will record their symptoms (cough, globus, NCCP, heart burn, and acid regurgitation) at daytime and nighttime everyday for 8 weeks. Symptoms suspecting drug adverse effect including nausea, diarrhea, constipation, headache, dizziness, fatigue, flatulence, etc will be recorded for 8 weeks.

After randomization, 60 subjects will receive oral lansoprazole (Takepron OD 30 mg, Takeda Co. Ltd, Tokyo, Japan) once daily before breakfast for 8 weeks. Subjects will record their symptoms (cough, globus, NCCP, heart burn, and acid regurgitation) at daytime and nighttime everyday for 8 weeks. Symptoms suspecting drug adverse effect including nausea, diarrhea, constipation, headache, dizziness, fatigue, flatulence, etc will be recorded for 8 weeks.

Compare the Response Rate of Atypical GERD After PPI Therapy

evaluate the response rate (symptom free) during the 8-week PPI therapy for atypical GERD between dexlansoprazole group and lansoprazole group

dexilansoprazole (Dexilant 60 mg)

lansoprazole (Takepron OD 30 mg)

Taipei Veterans General Hospital

Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD

Comparison of the Efficiency of Two Different PPI Formula in Treatment of Atypical GERD Patients, a Randomized Study

evaluate the response rate (symptom free) everyday during the 8-week PPI therapy for cough, globus sensation, NCCP, acid regurgitation, and heartburn respectively

the withdrawal or drop-out rate due to poor symptoms response or drug adverse effects

vghtpe user

Principal Investigator (and Clinical Professor)

Taipei Veterans General Hospital, Taiwan

a prospective, randomized, open-level clinical study to evaluate 8 weeks PPI response rate for atypical GERD

Pills equivalent to other study arm (10 mg)

Schizophrenia

Methotrexate 10mg once a week will be given for the first two weeks of the trial, followed by an increase in dose to 15mg or equivalent placebo once a week until week 16.

Methotrexate

Pills equivalent to the study drug arm (10mg) will be given once a week for the first two weeks of the trial, followed by an increase in dose to 15mg of equivalent placebo once a week until week 16.

Placebo Arm

Add-on Methotrexate for the Treatment of Schizophrenia

A Randomized Double Blind Parallel Trial Administering Methotrexate vs Placebo as add-on to Antipsychotics in Patients With Schizophrenia or Schizoaffecive Disorder

The positive score subscale has a minimum score of 7 and a maximum score of 49, 7 showing no symptomatology, and 49 showing very severe symptomatology

The PANSS scale has a minimum score of 30 and a maximum score of 210, 30 showing no symptomatology, and 210 showing very severe symptomatology

The negative score subscale has a minimum score of 7 and a maximum score of 49, 7 showing no symptomatology, and 49 showing very severe symptomatology

The general psychopathology subscale score has a minimum score of 16 and a maximum score of 112, 16 showing no symptomatology, and 112 showing very severe symptomatology

This is a clinical scale with a minimum score of 1 (not ill) and a maximum score of 7 (among the most extremely ill patients)

This is a clinical scale with a minimum score of 1 (very much improved) and a maximum score of 7 (very much worse)

This is a social functioning scale with a minimum score of 1 (no functioning) and a maximum score of 100 (excellent functioning)

The number of drop outs from the study will be analysed at the end of the study.

anxiolytic/proljev

Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD

Add-on Methotrexate for the Treatment of Schizophrenia

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