plasma samples and dosing of Sphingolipids

Diabetes Mellitus, Type 2

Diabetes Mellitus, Type 1

- Measuring the concentration of many species of sphingomyelins, ceramides, dihydroceramides and sphingosine

dosing of sphingolipids

Groupe Hospitalier Pitié-Salpêtrière

Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes

Three-hundred microlitres of plasma were used to quantify dihydroceramides, ceramides, sphingomyelins and sphingosine content. The lipid subspecies were extracted and analysed by Liquid Chromatography Mass Spectrometry (LC-MS/MS), at the Lipidomic Core Facility of the University of Bourgogne (Dijon, France).

Joe Elie Salem

Assistant director, clinical investigation center Paris Est

Groupe Hospitalier Pitie-Salpetriere

Each capsule contains 400 mg of eicosapentaenoic acid and 200 mg of docosahexaenoic acid. We allocated five capsules per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 2000 mg of eicosapentaenoic acid and 1000 mg of docosahexaenoic acid per day (3 grams of Omega 3 per day) by mouth for 12 weeks. The trademark is Omega Rx Dr.Sears Zone labs Inc.

Each capsule contains 600 mg of soybean oil. We allocated five capusles per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 3000 mg of soybean oil per day (3 gr soya oil per day) by mouth for 12 weeks.

Hypertriglyceridemia

Pediatric Obesity

Each capsule contains 400 mg of eicosapentaenoic acid and 200 mg of docosahexaenoic acid. We allocated five capsules per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 2000 mg of eicosapentaenoic acid and 1000 mg of docosahexaenoic acid per day (3 gr of Omega 3 per day) by mouth for 12 weeks. The trademark is Omega RX Dr.Sears Zone labs Inc.

Omega-3 fatty acid 3 grams per day

Placebo Comparator: Placebo Each capsule contains 600 mg of soybean oil. We allocated five capusles per day, three in the morning and two at night, every 12 hours (8.00 am and 8:00 pm), therefore the subject ingest 3000 mg of soybean oil per day (3 gr soya oil per day) by mouth for 12 weeks.

Placebo

Safety and Efficacy of Omega-3 Free Fatty Acids in Adolescents With Obesity and Hypertriglyceridemia.

A Randomized, Double Blind, Placebo-controlled Clinical Trial to Assess the Safety and Efficacy of Omega-3 Free Fatty Acids in Adolescents With Obesity and Hypertriglyceridemia.

Percent change in triglyceride from baseline to week 12 of study treatment

Fasting Triglycerides from baseline to week 12 of study treatment

Percent Change in cholesterol from baseline to week 12 of study treatment

Fasting Cholesterol from baseline to week 12 of study treatment

Percent Change in HDL-C from baseline to week 12 of study treatment

Fasting HDL-C from baseline to week 12 of study treatment

Percent Change in glucose from baseline to week 12 of study treatment

Fasting glucose from baseline to week 12 of study treatment

Percent Change in Uric Acid from baseline to week 12 of study treatment

Fasting Uric Acid from baseline to week 12 of study treatment

Blanca Estela Del Rio Navarro

Allergy and Pediatric Clinical Immunology

Hospital Infantil de Mexico Federico Gomez

Leija Martinez José de Jesús

Miranda Lora América Liliana

Hall Mondragon Margareth Sharon

Fengyang Huang

Randomized, double-blind, placebo-controlled clinical trial

The Masking intervention had made for investigation subjects and researchers

Healthy

Each subject received a palm olein-based run in diet for 2 weeks, followed by random assignment Test Fat Blue which incorporated into daily snacks (~50g of test fats, 2 experimental cupcakes (~15g test fat each) for breakfast and 4 pieces experimental cookies (~5g test fat each) for afternoon tea together with a palm olein-based background diet for 16 weeks.

Test Fat Blue

Each subject received a palm olein-based run in diet for 2 weeks, followed by random assignment Test Fat Green which incorporated into daily snacks (~50g of test fats, 2 experimental cupcakes (~15g test fat each) for breakfast and 4 pieces experimental cookies (~5g test fat each) for afternoon tea together with a palm olein-based background diet for 16 weeks.

Test Fat Green

Each subject received a palm olein-based run in diet for 2 weeks, followed by random assignment Test Fat Red which incorporated into daily snacks (~50g of test fats, 2 experimental cupcakes (~15g test fat each) for breakfast and 4 pieces experimental cookies (~5g test fat each) for afternoon tea together with a palm olein-based background diet for 16 weeks.

Test Fat Red

Multi-country Study- Effect of Dietary Fats on Fat Deposition

Multi-country Studies on the Effect of Positional Distribution of Fatty Acids at the Triglyceride Backbone of Vegetable Oils on Fat Deposition and Selected Health Outcome Measures - Malaysia

measured by magnetic resonance imaging (MRI) scan

measured by Tanita Segmental Body Fat Analysis

analysed by visceral adiposity index (VAI)

analysed by visceral body adiposity index (BAI)

analysed by enzyme-linked immunosorbent assay (ELISA) development kits

analyzed enzymatically by Siemens Advia 2400 Chemistry Analyzer

measured by Lipoprint® HDL Subfractions Test

measured by Lipoprint® LDL Subfractions Test

measured by Siemens Advia 2400 Chemistry Analyzer

FAC of faecal extracted fat measured by gas chromatography (GC)

Malaysia Palm Oil Board

International Medical University

Universiti Putra Malaysia

Cardiovascular Disease, Inflammation

High DHA

High EPA

Institute of Nutrition and Functional Foods (INAF), Laval University

Impact of EPA and DHA Supplementation on Plasma Biomarkers of Inflammation (n3)

Impact of EPA and DHA Supplementation on Plasma Biomarkers of Inflammation in Men and Women With Metabolic Syndrome

Change between treatments based on post-treatment values, adjusting for treatment-specific baseline values

Change between treatments based on post-treatment values

atherosclerosis/triacylglycerol

Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes

Safety and Efficacy of Omega-3 Free Fatty Acids in Adolescents With Obesity and Hypertriglyceridemia.

Multi-country Study- Effect of Dietary Fats on Fat Deposition

Impact of EPA and DHA Supplementation on Plasma Biomarkers of Inflammation (n3)

Effects of Ezetimibe Add-On to Statin Therapy on Adipokine Production in Obese and Metabolic Syndrome Patients With Atherosclerosis

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